Anti-CD27 Hamster Monoclonal Antibody [clone: LG.3A10] (PE)

: STEMCELL Technologies

Anti-CD27 Hamster Monoclonal Antibody [clone: LG.3A10] (PE)

: STEMCELL Technologies

Hamster (Armenian) monoclonal IgG1 antibody against human, mouse, rat CD27, PE-conjugated.

B cells
Nk cells
Other
T cells

The LG.3A10 antibody reacts with CD27, a 45 - 55 kDa member of the tumor necrosis factor receptor superfamily. CD27 is found on peripheral T cells, memory B cells, and NK cells and in mice has been found on most thymocytes, except CD46-CD8- precursors. CD27 and its ligand CD70 are involved in multiple aspects of T cell biology, including the costimulation and expansion of CD4+ and CD8+ T cells and differentiation to memory CD8+ T cells. CD27 interacts with TRAF family members, resulting in enhanced cellular proliferation and the induction of anti-apoptotic proteins. Additionally, CD27 plays important roles in T cell – B cell interactions and the maturation of effector T cells. The expansion of activated B cells and their differentiation to plasma cells is also reported to be enhanced by CD27.

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Type:
Antigen: CD27
Clonality: Monoclonal
Clone: LG.3A10
Conjugation: PE
Epitope:
Host: Hamster
Isotype: IgG1 kappa
Reactivity: Human, Mouse, Rat