Specifications
- Antibody type:Primary
- Antigen name:ABLIM1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Western blot:Yes
- Epitope:681-778/778
- Form:Liquid
- Gene ID:3983
- Antigen synonyms:Actin-binding double zinc finger protein|ABLIM1|RP11-317F20.1|RGD1565768|KIAA0059|abLIM-1|LIM actin binding protein 1|ABLM1_HUMAN|Actin-binding LIM protein family member 1|ABLIM-L|LIMAB1|ABLIM|ABLIM-S|Actin binding LIM protein 1|Actin binding LIM protein family member 1|Limatin|ABLIM-M|Actin binding double zinc finger protein|DKFZp781D0148|LIMAB 1|Actin-binding LIM protein 1|ABLIM 1|FLJ14564
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:88 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human ABLIM1
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumours, thus identifying ABLIM1 as a candidate tumour suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localised on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho Signalling) dependent activation of serum-response factor (SRF), thereby modulating transcription.
Type: Primary
Antigen: ABLIM1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 681-778/778
Host: Rabbit
Isotype: IgG
Reactivity: