Human Recombinant IL-15 (from E. coli)
Supplier: Shenandoah Biotechnology
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About this item
Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Therefore, IL-15 may serve as an effective therapeutic target, due to the beneficial outcomes of IL-15 neutralisation in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells.
- High quality
- Low endotoxin
- Affordable
Caution: This product is for research use only and is not for use in humans.
Specifications
- Conjugation:Unconjugated
- Protein function:Cytokine
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Storage conditions:–20 °C
- Endotoxin content:Endotoxin LAL (EU/µg) ≤0,1
- Biological activity:Bioactivity Assay: CTLL-2 cell proliferation, ED₅₀ ≤1 ng/ml, Bioactivity ≥1,0×10⁶ units/mg
- Gene ID:P40933
- Reconstitution instructions:Sterile water at 0,1 mg/ml
- Endotoxin-free:N
- Carrier-free:Y
- Protease-free:N
- Animal-free:Y
- Protein synonyms:IL-T
- Protein/peptide name:IL-15 (AF)
- Purity:≥97%
- Molecular weight:12,9 kDa
- Sequence:MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
- Endotoxin level:Low
- Formulation:10 mM Sodium bicarbonate, pH 8,5
- Nuclease-free:N
- Grade:RUO
- Shipping temperature:RT
- Tested applications:Bioassay
Specifications
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