Mouse Recombinant PDGF-BB (from E. coli)

Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation.

High quality
Low endotoxin
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IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17AF are active on mouse cells.

This functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. It is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues.

This dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB).

: A certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.

: For research use only.

Conjugation:
Unconjugated
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Mouse
Storage conditions:
−20 °C
Endotoxin content:
Endotoxin LAL (EU/µg) ≤1
Biological activity:
Bioactivity assay: 3T3 cell proliferation, ED50 ≤2 ng/ml, bioactivity ≥5,0×10⁵ units/mg
Gene ID:
P31240
Reconstitution instructions:
Sterile water at 0,1 mg/ml
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Animal-free:
N
Protein synonyms:
ODGF|GDGF
UniProtKB:
P31240
Protein/peptide name:
PDGF-BB
Purity:
≥95%
Molecular weight:
12,4/24,7 kDa
Sequence:
MSLGSLAAAE PAVIAECKTR TEVFQISRNL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRASQVQMRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETIVTPRPVT
Endotoxin level:
Low
Formulation:
10 mM sodium citrate, pH 3,0
Nuclease-free:
N
Grade:
RUO
Shipping temperature:
RT
Tested applications:
Bioassay