202387 Results for: "single-use assemblies&amp"

Supplier: Thermo Orion

The Thermo Scientific™ Orion™ Pro Star PI217 dual channel pH/ion bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star PI217 meter delivers advanced performance in a modern and simplified package.

Supplier: STEMCELL Technologies

Leptin is a protein produced from the ob gene or lep gene, and acts as both a hormone involved in metabolic function as well as a proinflammatory cytokine by inducing Th1 immune responses (Dunn et al.; La Cava; Newman and Gonzalez-Perez). Leptin is a member of the gp130 family of cytokines and is known to be correlated with obesity (Dixit et al.; Dunn et al.). Leptin can both promote osteogenesis via osteoblast receptors and inhibit it through its actions on the hypothalamus (Figenschau et al.). It is a small, non-glycosylated protein with a highly conserved sequence between species. Leptin binds to the leptin receptor OB-R, which exists in six isoforms in humans and can activate various Janus kinase (JAK) and downstream pathways (Dunn et al.; Münzberg and Morrison; Newman and Gonzalez-Perez). For example, the binding of leptin to LepRb receptor activates JAK2, which leads to the phosphorylation of both JAK2 and the LepRb receptor, with three separate residues on the receptor triggering signaling pathways for SHP-2, STAT5, and STAT3 (Dunn et al.; Münzberg and Morrison). In addition to its effects on mature immune cells, other studies have suggested impacts on other cell types, with activities such as inducing cell proliferation and morphological differentiation in hematopoietic cell lines, chondrocytes, and hepatic cells (Figenschau et al.; Gainsford et al.; Santos-Alvarez et al.; Wang et al.).

Supplier: VWR Collection

Digital shakers with microprocessor control which are ideal for mixing applications with heavy loads, e.g. cell cultures, solubility studies and extraction procedures. Variable speed control provides consistent, uniform shaking action. The Accu-drive shaking system delivers exceptional speed control, accuracy, safety and durability, the system continuously monitors shaking speed and will maintain the set point even under changing loads.

Supplier: STEMCELL Technologies

Trigger a variety of immunological responses with E. coli Lipopolysaccharide O55:B5 (S-form), a lipopolysaccharide (LPS) derived from the O55:B5 serotype of the Gram-negative bacteria and nbsp Escherichia coli. Composed of a lipid A, a core oligosaccharide, and an O antigen, LPS are glycolipid constituents that reside on the outer membranes of gram-negative bacteria (Kitchens RL et al.). LPS protects bacteria against bile salts and lipophilic antibiotics by maintaining the outer integrity of the cell membrane (Bäckhed F et al.). E. coli lipopolysaccharide O55:B5 (S-form), in particular, is predominantly recognized by toll-like receptor 4 (TLR4), which leads to the activation of NF-κβ, a protein complex which plays a key role in regulating immune response (Kuzmich N et al.). Activation of NF-κβ can trigger increased production of pro-inflammatory cytokines IL-1 and TNF-α by macrophages (Matuschak GM et al.). This LPS can also interact with CD14 to activate phospholipase Cγ2 and kinases of the Src family, trigger influxes of extracellular Ca2+, as well as calcineurin-dependent translocation of the nuclear factor of activated T cells (NFAT) family of transcription factors (Li CC et al.). When added to ImmunoCult™-SF macrophage medium (Catalog #10961), stimulation with lipopolysaccharide from E. coli (O55:B5) and IFN-γ supports the polarization to M1 (classically activated) macrophages. Warning: This product is highly pyrogenic. Avoid all means by which the product may enter the bloodstream.

Supplier: STEMCELL Technologies

Macrophage colony-stimulating factor (M-CSF) is a homodimeric glycoprotein growth factor that regulates proliferation and differentiation of myeloid hematopoietic progenitors to mononuclear phagocytic cell lineages, including monocytes, macrophages, and osteoclasts. M-CSF is a crucial factor for the development of tissue-resident macrophages in most tissues (Ginhoux andamp; Jung). It is required for the maturation and activation of monocytes and macrophages, and regulates inflammatory responses in conjunction with other stimuli such as IFN-γ, LPS, and IL-4 (Murray et al.). M-CSF is also required for bone resorption by osteoclasts, and is involved in the development and regulation of placenta, mammary gland, and brain. M-CSF is produced by monocytes, fibroblasts, osteoclasts, stromal cells, endothelial cells, and tumor cells (Chockalingam andamp; Ghosh). M-CSF exerts its biological effects by signaling through a receptor tyrosine kinase (CSF-1R or M-CSF-R) encoded by the c-fms proto-oncogene (Hamilton). CSF-1R shares similar structural features with other growth factor receptors, including the stem cell factor (SCF) receptor, platelet-derived growth factor receptor (PDGF-R), and Flt3/Flk-2 receptor tyrosine kinase. Stimulation of the CSF-1R upon binding to M-CSF activates MAPK, PI3K, and PLCγ signaling pathways (Chockalingam andamp; Ghosh). Human and mouse M-CSF sequences are highly conserved both at nucleotide and amino acid levels (80% homology; DeLamarter et al.).

Supplier: VWR Collection

The INCU-Line® Tower is a general purpose, dual-chamber, cooled incubator with natural convection. This digitally cooled incubator with Peltier technology offers an economical, space saving solution for microbiology applications at below room temperature. The built-in Peltier element has low energy consumption (only 35 W at 37 °C), and ensures temperature stability and uniformity over the entire temperature range.

Supplier: STEMCELL Technologies

Interleukin-8 (IL-8) is a member of the CXC subfamily of chemokines and is produced by leukocytic cells (monocytes, T cells, neutrophils, and natural killer cells) and non-leukocytic somatic cells (endothelial cells, fibroblasts, and epithelial cells), with the most prominent source being monocytes and macrophages. Its production is induced by inflammatory stimuli, such as IL-1. IL-8, also known as CXCL8, activates neutrophils inducing chemotaxis, exocytosis, and the respiratory burst (Baggiolini and Clark-Lewis; Mukaida). IL-8 is considered one of the most potent neutrophil chemoattractants in inflammation and binds to two different chemokine receptors on leukocytes: the G protein-coupled receptors CXCR1 and CXCR2 (Hoffmann et al.; de Oliveira et al.). IL-8 has angiogenic effects on human intestinal microvascular endothelial cells in vitro that are mediated by CXCR2 (Heidemann et al.). IL-8 is reported to promote breast cancer progression by increasing cell invasion, angiogenesis, and metastasis and has been reported to be involved in regulating breast cancer stem-like cells (Singh et al.). IL-8 also has proangiogenic properties in inflammatory diseases of the conjunctiva, cornea, iris, retina, and orbit (Ghasemi et al.). It was also shown that a major T cell effector function in human newborns is IL-8 production, which has the potential to activate antimicrobial neutrophils and gamma/delta T cells (Gibbons et al.). A variety of human pathogens, such as HIV and Mycobacterium tuberculosis, have been shown to induce IL-8 production by monocytes and macrophages (Friedland et al.; Meddows-Taylor et al.).

Supplier: Brand

PP. These 0,2 and 0,5 ml PCR tubes with attached caps are compatible with leading thermal cyclers with heated lids.

Supplier: VWR Collection

Digital shakers with microprocessor control which are ideal for mixing applications with very heavy loads and larger vessels, e.g. cell cultures, solubility studies and extraction procedures. Variable speed control provides consistent, uniform shaking action. The Accu-drive shaking system delivers exceptional speed control, accuracy, safety and durability, the system continuously monitors shaking speed and will maintain the set point even under changing loads.

Supplier: VWR Collection

The IL 23R digital cooled incubator with Peltier technology offers an economical and space saving solution for microbiology applications at below room temperature. The temperature can be freely adjusted in increments of 0,1 °C from 10 °C below ambient up to a maximum of 50 °C. The built-in Peltier element has a low energy consumption and ensures temperature stability and uniformity over the complete temperature range. The transparent Plexiglas® window allows full visibility of the samples inside the incubator. The housing is constructed entirely of epoxy coated mild steel.

Supplier: VWR Chemicals

Fast HiFi DNA Polymerase 2 U/µl is a proofreading DNA polymerase displaying the following features; high fidelity >60X Taq DNA Polymerase, ability to amplify problematic DNA targets, such as those with low to high GC content and ability to perform amplification on long DNA targets. lt is recommended for applications, which require extremely high fidelity such as cloning / sub cloning, NGS applications and mutagenesis.

Supplier: Liebherr

Glass/steel door refrigerators, Performance series with ceiling lighting and perfection series with vertical LED lighting provides optimal illumination of the interior over the entire height of the appliance.

Supplier: Brady

When you need to create product-identification and wire-marking labels, the product and wire identification suite is helpful to give solution.

Supplier: EPPENDORF

Eppendorf microplates provide exceptional stability during centrifugation with g-Safe® technology and efficient sample identification with the OptiTrack® Matrix. The design features, including RecoverMax® well design and raised well rims, ensure reliable sealing and facilitate maximum sample recovery.

Supplier: IKA

Labworldsoft 6 is a laboratory software to control lab devices, automate processes, and to document your measurements and results. The software provides access to a huge library of different laboratory devices.

Supplier: ANSELL MEDICAL PRODUCTS

These powder-free gloves with AMT Antimicrobial Technology reduce wearer exposure to pathogens. In addition, the antimicrobial surgical gloves have the potential to decrease the risk of surgical site infection (SSI).

Supplier: Thermo Orion

The Thermo Scientific™ Orion™ Pro Star PC215 pH/ion and conductivity bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star PC215 meter delivers advanced performance in a modern and simplified package.

Supplier: Testo

This one-hand, robust food penetration pH/°C measuring instrument comes with automatic temperature compensation. The robust penetration measuring tip is interchangeable and not affected by dirt and dust thanks to the hole diaphragm. The instrument is especially well suited to pH measurements in semi-solid media such as meat.

Supplier: IKA

Magnetic hotplate stirrer with extremely fast heating times and integrated temperature control, suitable for unsupervised operation. Units have bushing according to DIN 12878 for connecting a contact thermometer, e.g. ETS-D5, enabling precise temperature control. Features include high magnetic adhesion, electronic speed control and digital error code display.

Supplier: ANSELL MEDICAL PRODUCTS

These disposable gloves are specifically designed to meet the demanding requirements of microsurgery. The gloves feel like a second skin. The thin layer of latex film (20% thinner than a standard powder-free latex surgical glove) in combination with their mild textured surface provide perfect levels of sensitivity and tactility, thus ensuring a confident grip on instruments at all times.

Supplier: IKA

The T 25 easy clean control is a high-performance dispersing instrument with electronic speed control from 3000 to 25000 rpm for working volumes of 1 to 2000 ml (H2O). The S 25 EC-T-C-18G-ST tool allows temperature measurement and operation time detection through RFID. Device overheating is prevented by continuous temperature monitoring and the setting of temperature limits. The detection of operating time serves to guarantee regular maintenance.

Supplier: Thermo Fisher Scientific

These Nunc™ cell culture flasks are designed for culture consistency, cell health, and reproducibility. Choose from a variety of surfaces and sizes with culture areas ranging from 25 to 500 cm² to suit your specific applications and cell types.

Supplier: Honeywell Chemicals

Coulometric Karl Fischer titrations normally require two reagent solutions: an anolyte (the solution in the anodic compartment) and a catholyte (the solution in the cathodic compartment).

Supplier: Portwest

A sustainable version of a best selling basic vest, the Eco Hi-Vis Vest is manufactured from 100% recycled polyester. It has a classic reflective tape configuration that will ensure wearers are seen.

Supplier: IKA

Low profile laboratory shaker with digital display which has a large mounting surface. Continuous operation is guaranteed even under extreme loads. Ideal for larger vessels of 250 ml and over, e.g. round bottomed flasks, Erlenmeyer flasks, culture flasks and bottles. Variety of different vessels can be accommodated by choosing from the range of optional holding attachments (not included with shaker).

Supplier: VWR Collection

VWR® Bead Mill MAX is the premier model in the VWR Bead Mill homogeniser range. VWR Bead Mill MAX is designed to grind, lyse or homogenise the most difficult samples with repeatable results. The unique tube carriage motion ensures the intra-tube bead movement reduces swirling, and creates the highest bead impact force of any bead mill on the market.

Supplier: G-Biosciences

The majority of genomic DNA extraction methods involve numerous physical manipulations, including mixing, pipetting, shaking, binding to resin, elution, which results in sheared DNA that may not be suitable for further analysis.

Supplier: VWR Collection

This user friendly instrument, with articulated electrode stand and IP 43-rated housing, provides high resolution and accuracy for precise measurements. Complete with USB output for connection to a computer. GLP compliant.

Supplier: MP Biomedicals

The Fast DNA™ SPIN Kit for Soil is designed to efficiently isolate bacterial, fungal, plant and animal genomic DNA from soil and other environmental samples. It quickly and efficiently isolates PCR-ready genomic DNA directly from soil samples in less than 60 minutes.

Supplier: Cytiva

Sera-Xtracta virus/pathogen kit for high-throughput total nucleic acid (DNA/RNA) isolation from bacteria and viruses including adenovirus (type 14), influenza A (H3N2) and COVID-19.