"Stemcell Technologies"

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD32, unconjugated.

Supplier: Stemcell Technologies

Rat monoclonal IgG2a antibody against mouse CD150 (SLAM), biotin-conjugated.

Supplier: Stemcell Technologies

Column-free immunomagnetic positive selection of human CD56+ cells for HLA analysis

Supplier: Stemcell Technologies

For detection and measurement of compounds that inhibit binding of viral SARS-CoV-2 Spike protein to human ACE2 receptor.

Supplier: Stemcell Technologies

Iscove's Modified Dulbecco's Medium (IMDM) with 25 mm HEPES.

Supplier: Stemcell Technologies

Rabbit polyclonal antibody against human, mouse, rat TBR1 (IDDAS).

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against mouse, rat, guinea pig CD90/CD90.1, APC-conjugated.

Supplier: Stemcell Technologies

Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells cultured in mouse embryonic fibroblast (MEF)-conditioned medium (Chaturvedi et al.), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba et al.). Noggin is essential for development of ectodermal structures including neural tube, tooth, hair follicle, and eye, as well as patterning of mesodermal somites and skeletal structures. It also influences chondrogenesis, osteogenesis, and joint formation (Krause et al.).

Supplier: Stemcell Technologies

Transforming growth factor (TGF) beta 3 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. TGF-beta 3 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins, thus regulating a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (Massagué; McDowell et al.). TGF-beta 3 enhances glycosaminoglycan production by mesenchymal stromal cells, stimulates scar-free healing, and improves glucose tolerance and phenotypic changes in adipocyte morphology (Hall et al.; Holton et al.). TGF-beta 3 induces proliferation of posterofrontal suture-derived mesenchymal stromal cells, and stimulates expression of fibroblast growth factors 2 and 18 (James et al.). This product is animal component-free.

Supplier: Stemcell Technologies

Biopreservation reagent for cells and tissues.

Supplier: Stemcell Technologies

Defined supplement for improving survival of human ES and iPS cells in single-cell workflows.

Supplier: Stemcell Technologies

Interleukin 19 (IL-19) is a member of the IL-10 cytokine family and is produced by keratinocytes, B cells, and monocytes (Romer et al.; Wolk et al.). Expression of IL-19 can be induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS; Gallagher et al.). IL-19 is considered to be a proinflammatory cytokine, as it upregulates IL-6 and tumor necrosis factor alpha (TNF-α; Liao et al. 2002). IL-19 binds the IL-20 receptor complex (IL-20R) which comprises IL-20R alpha and IL-20R beta to activate the STAT3 pathway (Dumoutier et al.). IL-19 also induces T-helper cell differentiation towards a Th2 response, resulting in the production of IL-10 and additional IL-19 (Liao et al. 2002; Liao et al. 2004). IL-19 has been implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD20, FITC-conjugated.

Supplier: Stemcell Technologies

Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits. IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils and B cells in response to bacterial products and cytokines such as IFN-γ. The IL-12 receptor is expressed on T, NK, and dendritic cells. Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford et al.). It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann and Rüde). Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford et al.).

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD45, FITC-conjugated.

Supplier: Stemcell Technologies

For characterisaton of hPSC-derived progenitor cells of definitive endoderm, hepatic, intestinal, or pancreatic lineages.