"Other Essentials"

Supplier: Merck

The certified reference material (CRM) is intended to be used as a calibrant for chromatography and other analytical techniques. The iprobenfos CRM may also find following uses:

Supplier: MERCK PRODUCTION CHEMICALS

Tris(hydroxymethyl)aminomethane (TRIS, Trometamol), EMPROVE® ESSENTIAL BP, Ph. Eur., USP, JPC suitable for use as excipient, SAFC®

Supplier: Bioss

Mapping to chromosome 21, the FASP1 gene (FAPP1-associated protein 1) encodes a 233 amino acid protein that is homologous to the fission yeast protein Mis18. In yeast, Mis18 is localized to the centrosome and forms a complex with Mis16 to maintain the deacetylated state of histones specifically in the central core of centromeres. FASP1, also known as Protein Mis18-alpha and C21orf45, is required for the recruitment of CENP-A to centrosomes and is thereby essential for normal chromosome segregation during mitosis. With expression in testis, FASP1 exists as a homodimer, a heterodimer with MIS18B or is present in a complex containing other Mis18 family members. FASP1 has been shown to bind to pp5644 in Hela cells, where overexpression of pp5644 leads to inhibited growth and colony formation.

Supplier: G-Biosciences

Concanavalin A (Con A) agarose consists of Con A coupled to 6% agarose by the cyanogen bromide method. Con A is a tetrameric metalloprotein lectin isolated from Canavalia ensiformis (jack bean). It is used for the purification of glycoproteins, polysaccharides and glycolipids as it binds molecules containing α-D-mannopyranosyl, α-D-glucopyranosyl and sterically related residues. It has also be used in other application areas including purification of enzyme-antibody conjugates, purification of IgM and separation of membrane vesicles. As stated above, it is a metalloprotein and to maintain its binding characteristics the presence of both Mn²⁺ and Ca²⁺ is essential. Each subunit of Con A utilises one calcium and one manganese ion and these cations can be removed under acidic conditions abolishing the carbohydrate-binding activity.

Supplier: Bioss

The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Supplier: MERCK PRODUCTION CHEMICALS

Calcium carbonate, EMPROVE® ESSENTIAL FCC, BP, Ph. Eur., JP, USP suitable for use as excipient (max. 0.002% Fe), precipitated, SAFC®

Supplier: AAT Bioquest

Monochloromobimane (mBCl) is essentially nonfluorescent until reacted with a thiol group.

Supplier: Sartorius

These qualitative filter papers are essentially used for analytical purposes and routine analyses, whenever no gravimetric analyses are required. They are wet-strengthened and can be used for pressure and vacuum filtration. They are made of refined pulp and linters with an >95% alpha-cellulose content, are very pure with an ash content <0,1%.

Supplier: AAT Bioquest

Cy3® dye is one of the most common cyanine dyes used for labeling proteins, nucleic acids and other biological molecules.

Supplier: AAT Bioquest

SoNa™ 520 is a new sodium-sensitive fluorescent indicator dye used to detect sodium levels in cells and other biological samples.

Supplier: Merck

These stands ensure that your cylinder will be stable on a benchtop or other flat surface.

Supplier: Avantor

The quality of many BAKER ANALYZED™ Reagents meets or exceeds the requirements set forth by the American Chemical Society (ACS). These solvents are essential for any chemical stockroom.

Supplier: Bioss

Essential for mesoderm formation and axial patterning during embryonic development.

Supplier: ProSci Inc.

SESTD1 Antibody: SESTD1 was initially identified in mutant zebrafish with defects in the spontaneous contraction and touch response as a novel gene, solo, encoding a protein containing SEC14 and spectrin repeat domains. Other experiments indicated that SESTD1 interacts with the TRPC4 and TRPC5, members of the transient receptor potential channel family, via the TRPC calmodulin- and inositol 1, 4, 5-triphosphate receptor-binding domain and is essential for efficient receptor-mediated activation of TRPC5, suggesting that SESTD1 is a novel regulator of these TRPC proteins.

Supplier: ProSci Inc.

CDC23 shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.

Supplier: MERCK PRODUCTION CHEMICALS

Calcium chloride dihydrate, EMPROVE® ESSENTIAL E509, FCC, BP, Ph. Eur., JP, USP, SAFC®