44825 Results for: "4-Fluoro-alpha-methylstyrene"

Supplier: Bioss

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.

Supplier: Alpha Laboratories

3 inch standard Pasteurpipette, 87mm pk500 1 * 500 items

Supplier: Alpha Laboratories

CELLASGEL 250 MICRON 5.7X14 1 * 25 items

Supplier: Alpha Laboratories

SCREW CAPS RED APEX 1 * 500 items

Supplier: Alpha Laboratories

SEALPLATE FILM PACK OF 100 1 * 100 items

Supplier: Alpha Laboratories

BLOCK MODULE FOR B-48DA -WITHOUT HOT-LID 1 * 1 items

Supplier: Alpha Packaging

Radiation/radioactive waste bag clear boxed, 455x760mm pk/50 1 * 50 items

Supplier: Alpha Laboratories

RACK 4-WAY INTERLOCKING COMBIRACK ASSORTED COLOURS AUTOCLAVABLE PACK OF 5 WITH 4 ORIENTATIONS TO ACCOMMODATE 0.5ml 1.5ml 2.0ml 15ml and 50ml 1 * 5 items

Supplier: Alpha Laboratories

SCREW CAP APEX BLUE NS PK OF 500 1 * 500 items

Supplier: Alpha Laboratories

SHIPPING - 25 1 * 240 items

Supplier: Alpha Laboratories

Unbreakable aspirator Pasteurpipette 152mm 20 sterile 25s 1 * 500 items

Supplier: Alpha Laboratories

LINER APET 54X34CM FOR USE WITH GENERAL 1 * 25 items

Supplier: Alpha Laboratories

2.0ML APEX SCREW-CAP MICROCENTRIFUGE TUB 1 * 500 items

Supplier: Roth Carl

A-CHACONINE 1 * 5 mg

Supplier: Merck Millipore (Calbiochem‎)

Pifithrin-A 10mg 1 * 10 mg

Supplier: Roth Carl

a-D(+)-Glucose monohydrate 1 * 5 kg

Supplier: Roth Carl

a-Naphthyl acetate 1 * 25 g

Supplier: Alpha Laboratories

Ultra Fine-Tip Paddle Pastette 1 * 500 items

Supplier: Alpha Laboratories

1-5ml pipettor/pipette tips,natural, pk250 loose 1 * 250 items

Supplier: Alpha Laboratories

PASTEUR PIPET DUAL BULB, 60µL 1 * 5.000 items

Supplier: Alpha Laboratories

Graduated Medi Pastette Sterile 20's 1 * 500 items

Supplier: Alpha Laboratories

5ml Graduated Pastette Sterile 20's 1 * 240 items

Supplier: Alpha Laboratories

DEEP WELL PLATE, 1.2ML, PP, STERILE 1 * 24 items

Supplier: Alpha Laboratories

MICRO CAPILLARY TIPS, 1-200UL STERILE 1 * 1.020 items

Supplier: Alpha Laboratories

Serological Pipette Graduated 5ml Plastic Plugged Sterile Sterilin Individually Paper Peel Wrapped 4 Packs of 50 ideal for tissue c ulture work 1 * 200 items

Supplier: Merck Millipore (Calbiochem‎)

Tumor Necrosis Factor-A Antagonist 1 * 1 mg

Supplier: Roth Carl

a+ß-Thujone (isomers) 1 * 5 g

Supplier: Roth Carl

2-Phenylindole 1 * 50 g

Supplier: Alpha Laboratories

Tip Low-Retention Paradigm™ 1-10µl Extended Filtered Racked Sterile 46mm 1 * 1 items

Supplier: Alpha Laboratories

SAMPLETITE PRIME JAR 120ML CLEAR NS 1 * 500 items