Specifications

Antigen name:
Glycophorin A/B
Antigen symbol:
CD235ab
Clonality:
Monoclonal
Clone:
HIR2 (GA-R2)
Conjugation:
Biotin
Host:
Mouse
Isotype:
IgG2b kappa
Reactivity:
Human
Gene ID:
2993/2994
Pk:
100 µG

Specifications

About this item

Mouse monoclonal IgG2b antibody against human CD235ab (glycophorin A/B), biotin-conjugated.

Red blood cells

The HIR2 (GA-R2) antibody recognizes an epitope common to the N-terminal region of human CD235a (glycophorin A) and CD235b (glycophorin B), homologous type I sialoglycoproteins of the erythrocyte (red blood cell) membrane that bear the antigenic determinants for the MN and Ss blood groups. CD235ab is expressed on early- and late-stage erythroblasts, mature erythrocytes, and erythroid cell lines such as K562 and HEL, but not on other cell types. CD235a is abundantly expressed whereas CD235b is a relatively minor membrane component. The proteins are believed to provide a large mucin-like surface to erythrocytes that acts to minimize aggregation in the circulation. The HIR2 antibody binds with higher affinity to CD235a than CD235b, and agglutinates untreated erythrocytes.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD235ab
Clonality: Monoclonal
Clone: HIR2 (GA-R2)
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human