Anti-NK1.1 (CD161) Mouse Monoclonal Antibody [clone: PK136] (APC)

Supplier: STEMCELL Technologies

Certificates

Supplier: STEMCELL Technologies

About this item

Mouse monoclonal IgG2a antibody against mouse NK1.1 (CD161), APC-conjugated.

Nk cells

The PK136 antibody reacts with murine NK1.1 (CD161), an ~80 kDa homodimeric type 2 transmembrane glycoprotein and C-type lectin receptor expressed on NK cells, NK-T cells, and rare subsets of T cells and monocytes in select strains of mice. NK1.1 is encoded by the Klrb1b and Klrb1c genes, which specify CD161b and CD161c polypeptides, respectively. CD161b is expressed only by Swiss NIH and SJL mice, and CD161c by certain strains such as C57BL, FVB/N, and NZB (but not A, AKR, BALB/c, CBA/J, C3H, C57BR, C58, DBA/1, DBA/2, NOD, SJL, or 129). NK1.1 has functional roles in modulating several processes, including the activation and proliferation of NK cells, induction of interferon-γ production, and release of cytotoxic granules. Its expression on the cell surface is specifically upregulated by IL-12. For detection of NK cells in NK1.1- strains, Anti-mouse CD49b Antibody, Clone DX5 (Catalog #60020) is recommended. DX5 recognizes CD49b (integrin α2), another commonly used NK cell marker.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type: Anti-NK1.1 (CD161) Mouse Monoclonal Antibody [clone: PK136] (APC)
Antigen: NK1.1 (CD161)
Clonality: Monoclonal
Clone: PK136
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Mouse