Innovative Alternative to LNPs for mRNA Therapeutics, in vivo-jetRNA®+, Polyplus-transfection

In vivo-jetRNA®+ is a ready-to-use, efficient and stable lipid-based transfection reagent optimized for in vivo mRNA delivery.

• Efficient: 100% mRNA encapsulation leading to comparable LNP delivery results
• Time saving: Ready-to-use reagent that does not require formulation equipment
• Stable: Maintain liposome size using low to high mRNA concentration over time
• Universal: Target any organ/tissue using various administration routes
• Safe: Maintain healthy animals and organs

In vivo-jetRNA®+ is a lipid-based transfection reagent composed of preformed liposomes specifically developed to deliver mRNA in vivo. In vivo-jetRNA®+ has been carefully optimized by Polyplus and can be used with a simple and straightforward protocol without any formulation step (contrary to lipid nanoparticles). This reagent can be used to target unique or multiple organs, by using systemic injection routes, in various animal models (mice, rat, etc.).

Certifications: Polyplus® has been an ISO 9001 accredited company since 2002. Since then this certification has been successfully renewed every 3 years.