- Antibody type:Primary
- Antigen name:PRMT5
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western blot:Yes
- Epitope:201-300/637
- Form:Liquid
- Gene ID:10419
- Antigen synonyms:SHK1 KINASE BINDING PROTEIN 1|SKB1|S. POMBE|SKB1: SKB1 homolog S. pombe|Protein arginine N-methyltransferase 5|SHK1 KINASE-BINDING PROTEIN 1|Shk1 kinase binding protein 1 homolog|SKB 1|Protein arginine N methyltransferase 5|Histone-arginine N-methyltransferase PRMT5|PRMT 5|ANM5_HUMAN|HRMT1L5|SKB1 homolog|IBP72|S. POMBE HOMOLOG OF|SKB1Hs|Protein arginine methyltransferase 5|HMT1 hnRNP methyltransferase like 5|JBP1|PRMT5|72 kDa ICln binding protein|HOMOLOG OF|Jak-binding protein 1|72 kDa ICln-binding protein|Shk1 kinase-binding protein 1 homolog|JBP 1
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:70 kDa
- Storage temperature:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human PRMT5
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localisation to the meiotic nuage. Methylates RPS10.
Type: Primary
Antigen: PRMT5
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 201-300/637
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse
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