Anti-JNK1 / JNK2 / JNK3 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

BOSSBS-2592R-A647

Anti-JNK1 / JNK2 / JNK3 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

BOSSBS-2592R-A647

Antibody type:
Primary
Antigen name:
c-Jun N-terminal kinase 1, c-Jun N-terminal kinase 2, c-Jun N-terminal kinase 3
Antigen symbol:
JNK1 / JNK2 / JNK3
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 647
Host:
Rabbit
ImmunoChemistry:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Environmentally Preferable:
Cross adsorption:
No
Form:
liquid
Gene ID:
26419,26420,26414
Antigen synonyms:
stress-activated protein kinase 1c|MAPK10|JNK3|JNK3A|stress-activated protein kinase 1|JNK1A2|SAPK1a|Stress-activated protein kinase 1b|SAPK1|MAP kinase 10|MAP kinase p49 3F12|Mitogen-activated protein kinase 9|JNK-55|mitogen-activated protein kinase 8 isoform JNK1 alpha1|PRKM9|c-Jun N-terminal kinase 2|PRKM8|JNK-46|SAPK1A|Stress-activated protein kinase JNK3|JNK|MAP kinase 9|SAPK1B|MAPK9|JNK2|MAP kinase 8|JNK1|SAPK1c|SAPK1b|PRKM10|c-Jun N-terminal kinase 1|JUN N-terminal kinase|Stress-activated protein kinase JNK2|MAPK8|MAPK 10|Stress-activated protein kinase 1a|JNK21B1/2|mitogen-activated protein kinase 8 isoform JNK1 beta2|Mitogen-activated protein kinase 10|MAPK 9
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature:
Store at 4°C for 12 months
Concentration:
1 μg/μl
Shipping temperature:
4°C
Immunogen:
160-210/384
Purification:
Purified by Protein A
Pk:
100 µl

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: JNK1 / JNK2 / JNK3
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat