2435 Resultater for: "STEMCELL Technologies"

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of mouse cells labeled with APC-conjugated antibodies.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human naïve pan T cells.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human basophils.

Supplier: STEMCELL Technologies

For detection and measurement of human interleukin 4.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of any cells labeled with FITC-conjugated antibodies.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of any human cells labeled with biotinylated antibodies.

Supplier: STEMCELL Technologies

Supplement for the expansion and differentiation of lymphoid progenitor cells.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of human CD34+ cells (e.g. hematopoietic, stem/progenitor cells)

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of human CD34+ cells from whole blood or buffy coat.

Supplier: STEMCELL Technologies

Reliably isolate mononuclear cells from peripheral blood, cord blood, or bone marrow with Lymphoprep™, a cost-effective alternative to Ficoll-Paque™.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human monocytes

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human T cells.

Supplier: STEMCELL Technologies

Differentiation and maturation kits for generation of motor neurons from human pluripotent stem cells.

Supplier: STEMCELL Technologies

Rabbit polyclonal antibody against human lysozyme.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human cells

Supplier: STEMCELL Technologies

EasySep™ buffer is required for use with EasySep™ cell isolation kits that are in vitro diagnostic (IVD) medical devices for use with downstream diagnostic assays. EasySep™ buffer is an accessory to an in vitro diagnostic (IVD) medical device in Canada, Europe, the United Kingdom and the United States. EasySep™ buffer is indicated for in vitro diagnostic use by laboratory professionals.

Supplier: STEMCELL Technologies

Ideal for fixing cells prior to permeabilisation, fixation buffer can be used with Intracellular Permeabilisation Buffer (10X) to conduct intracellular staining for flow cytometry. This fixation buffer can also be used to preserve fluorescently labeled cells prior to analysis by flow cytometry.

Supplier: STEMCELL Technologies

Cell culture medium kit for robust generation of midbrain neural organoids from human pluripotent stem cells.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against mouse CD127, PE-Cy7-conjugated.

Supplier: STEMCELL Technologies

Hamster (Armenian) monoclonal antibody against mouse CD80 (B7-1), PE-conjugated.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against mouse CD86 (B7-2), APC-conjugated.

Supplier: STEMCELL Technologies

Stabilised, feeder-free maintenance medium for human ES and iPS cells optimised for single-cell passaging.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against mouse Ly-6C, PerCP-Cy5.5-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal antibody against human CD154 (CD40L).

Supplier: STEMCELL Technologies

Use Interleukin 37 (IL-37) to inhibit the expression of inflammatory cytokines, such as IL-6, MIP-1α, MIP-1β, and TNF-α, in a MAPK-dependent manner (Qi et al.). A secreted protein belonging to the interleukin-1 cytokine family, IL-37 acts as an anti-inflammatory alarmin, with predominant expression in monocytes, and constitutive secretion by myeloid dendritic cells (Rudloff et al.). IL-37 has been shown to limit inflammation in human blood M1 macrophages by binding to extracellular surface receptors, requiring IL-1R8 as a coreceptor (Li et al.). It also has protective effects against obesity-induced inflammation and insulin resistance, reducing adipogenesis and activating AMPK signaling both in vitro and in vivo (Ballak et al.). In humans, the IL-37 gene undergoes alternative splicing, resulting in multiple isoforms of the protein (Boraschi et al.). For consistency and reproducibility across your applications, Interleukin 37 from STEMCELL comes lyophilised with ≥93% purity.

Supplier: STEMCELL Technologies

Complement factor D is a component of the alternative pathway of the complement system and part of the innate immune system, playing a vital role in the initiation and amplification of complement activation, in order to defend against infection (Barratt and Weitz). A serine protease belonging to the S1 peptidase family, complement factor D is secreted by adipocytes into circulating blood, and is also expressed by macrophages and monocytes (White et al.). In the initiation phase of the complement pathway, complement factor D cleaves complement factor B (bound to component C3) to produce a complex known as C3 convertase. During the amplification phase, complement factor D cleaves complement factor B (bound to component C3b) to produce the C3bBb convertase, and is involved in the propagation of complement activation. In addition to its immunological role, complement factor D is involved in other physiological processes, such as the efficient clearing of damaged cell debris by phagocytes following acute liver injury (Cresci et al.). Complement factor D deficiency is associated with an increased susceptibility to pathogens like Neisseria meningitidis (Biesma et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, complement factor D from STEMCELL comes lyophilised with ≥94% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.

Supplier: STEMCELL Technologies

Butyrophilin 1A1 (BTN1A1) is a glycoprotein belonging to the butyrophilin (BTN) family which collectively modulates immune responses, through excitatory and inhibitory signals targeting immune cells. Butyrophilins are composed of two extracellular immunoglobulin domains and a transmembrane region, with a conserved B30.2 domain (PRYSPRY) that is present in most members (Malinowska et al.). BTN1A1, along with BTN2A2, has been shown to inhibit the proliferation of CD4+ and CD8+ T cells, modify T cell metabolism, and affect the expression of IL-2 and IFN-γ (Smith et al.). Due to these modulatory effects on T cells, BTN1A1 may have a role in inhibiting the development of autoimmune diseases (Stefferl et al.). BTN1A1 is also expressed in mammary glands and is required for the secretion of milk lipids during lactation (Ogg et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, Serpin A12 from STEMCELL comes lyophilised with ≥92% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.

Supplier: STEMCELL Technologies

Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.). RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

Use hepassocin to bind to lymphocyte-activation gene 3 (LAG-3) in an MHC class II independent manner, and inhibit antigen-specific T-cell activation (Wang et al.). Hepassocin is known to play a restorative role in the liver, reducing apoptosis and accelerating hepatocyte proliferation in vivo (Li et al.). In addition to these hepatoprotective effects, studies have shown that hepassocin expression is upregulated in gastric cancer tissues (Zhang et al.) and in breast cancer cells (Du et al.), suggesting it has potential to predict cancer disease progression. Hepassocin is a member of the fibrinogen superfamily, whose members share a fibrinogen domain at their C-terminus. It is predominantly expressed in the liver, and weakly in the pancreas (Hara et al.), and is secreted as a homodimer that consists of 312 amino acids. Hepassocin is an acute-phase reactant whose expression in HepG2 cells has been shown to be regulated by IL-6 (Liu and Ukomadu). This protein product contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, hepassocin from STEMCELL comes lyophilised with ≥87% purity, and endotoxin levels are verified to be ≤1,0 EU/μg protein.

Supplier: STEMCELL Technologies

Apolipoprotein H (apo H) has been shown to promote the coagulation of blood platelets by inhibiting thrombomodulin complex and inactivating protein C (Keeling et al.), but can also act as an anticoagulant by binding thrombin and inhibiting its procoagulant effects (Pozzi et al.). Belonging to the lipid-binding apolipoprotein family, within the lipocalin superfamily, apo H is a protein constituent of plasma, with a high affinity for negatively charged phospholipids. The structure of apo H reveals four N-terminal complement control protein (CCP) modules, also known as 'sushi' domains, and a distinct fifth C-terminal domain with four antiparallel beta sheets, two alpha-helices, and an extended loop (Schwarzenbacher et al.). Apo H is the main antigen implicated in antiphospholipid syndrome (APS), an autoimmune condition involving pregnancy complications and vascular thrombosis (Brusch). Studies have also reported that Apo H is involved in the progression of atherosclerosis (Harats and George). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apolipoprotein H from STEMCELL comes lyophilised with ≥93% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.