"Other Essentials"

Supplier: Abcam

Anti-FAK (phospho Y397 + Y576 + Y925) antibody [RM1141] is a Rabbit Recombinant Multiclonal antibody that is used in FAK (phospho Y397 + Y576 + Y925) Dot Blot, Western Blot. Suitable for Human, Mouse, Rat samples. FAK (PTK2) is a non-receptor protein-tyrosine kinase which is involved in regulation of a number of essential cellular processes, including cell cycle progression, cell migration, actic cytoskeleton organisation and formation of focal adhesions. FAK is activated by phosphorylation and recruited to focal adhesions in response to integrin signalling. Aberrant expression of FAK may play a role in tumor formation, including ovarian, breast and non-small cell lung cancers.

Supplier: Biosensis

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Supplier: Thermo Fisher Scientific

Pierce™ Recombinant Peroxidase Conjugated Protein A can be used to probe and detect rabbit and human antibodies, especially IgG isotypes, in Western blotting, ELISA, IHC and other immunoassay protocols.

Supplier: Abcam

Anti-CRBN antibody [EPR28739-64] is a Rabbit Monoclonal antibody that is used in CRBN Flow Cytometry (Intra), IP, Western Blot. Suitable for Human, Mouse samples. Cereblon (CRBN) is a multifunctional protein located in the cytoplasm, nucleus, and peripheral membranes of the human tissues. CRBN is closely related to the proliferation and metabolism of normal cells as well as tumor cells.It is part of the CRL4 CRBN ubiquitin E3 ligase complex, which is crucial for the action of immunomodulatory drugs (IMiDs) like lenalidomide and pomalidomide. These drugs bind to CRBN, leading to the degradation of transcription factors Ikaros and Aiolos, which are essential for myeloma cell survival. Additionally, novel cereblon E3 ligase modulators (CELMoDs) are being developed to overcome resistance to IMiDs, offering new therapeutic options for patients with CRBN mutation.

Supplier: VWR Collection

PFAS PP short thread caps or PE snap ring caps, light green, with hole. White silicone/transparent polypropylene, for PFAS analysis.

Supplier: MP Biomedicals

An essential fatty acid, and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and is a constituent of animal phosphatides.

Supplier: BOEKEL SCIENTIFIC

RapidFISH slide hybridisation oven was designed to simplify fluorescent in-situ hybridisations procedures for FFP samples, cell suspensions, and other tissue preparation procedures.

Supplier: Cayman Chemical

S396A mutant (from E. coli)

Supplier: MP Biomedicals

Tryptone is a pancreatic digest of casein, utillised as a source of nitrogen in many culture media for growing bacteria as well as fungi.

Supplier: Merck

MVP ICON® portable hygiene monitoring system – setting a new standard.

Supplier: AAT Bioquest

Optimised for CytoCite™ and Qubit™ fluorometers. The Portelite™ fluorimetric protein quantitation kit is significantly more sensitive than existing colorimetric protein measurements, e.g., Bradford and Bicinchoninic acid (BCA) assays.

Supplier: Boster Bio

Rabbit IgG polyclonal antibody for NLR family CARD domain-containing protein 4(NLRC4) detection. Tested with WB in Human;Mouse;Rat.

Supplier: Abcam

Anti-Fas antibody [EPR24898-74] is a Rabbit Monoclonal antibody that is used in Fas IHC-Fr, IHC-P, IP, Western Blot. Suitable for Mouse samples. FAS, also known as CD95 or APO-1, is a cell surface receptor that plays a significant role in regulating apoptosis (programmed cell death). FAS is crucial for inducing apoptosis in cancer cells. When FAS binds to its ligand (FASL), it triggers a cascade leading to cell death, which is essential for eliminating cancer cells.FAS was identified as an independent prognostic marker for recurrence free survival in breast cancer, with large variation in expression by receptor subtypes. Interestingly, the prognostic effect of CD8+ TILs in ER-negative disease was only valid for tumors with a high FAS expression.FAS expression might therefore act as a predictive factor for new emerging therapies.Researchers are exploring ways to enhance FAS signaling to prevent cancer relapse and improve the durability of immunotherapy responses.

Supplier: Genscript

Efficient and gentle cell separation based on surface markers is essential for researching specific cell populations, and for developing life-saving cell and gene therapies. GenScript has renowned expertise in developing magnetic bead products for bioseparation of various types of biomolecules. The CytoSinct™ Cell Separation Technology uses perfected nanoparticle empowered immunomagnetic separation technology to isolate specific cell populations of interest, combining the specificity and sensitivity of antibody-based purification with the gentleness of nanoparticles and the ease and speed of magnetic separation.

Supplier: CONTEC

The lightweight, stainless steel EasyReach™ Cleaning Tool is designed for cleaning isolators, laminar air flow hoods, glove boxes, and other mini environments. Rectangular shape makes overlapping straight-line action easy to achieve. Hinged joint and lightweight design makes one-handed cleaning comfortable and improves access to hard-to-reach areas.

Supplier: MP Biomedicals

D-Pantothenic acid is an essential vitamin (except in horses, ruminants). Pantothenic acid is involved in a number of biological reactions including: A precursor in the biosynthesis of coenzyme A, production of energy, catabolism of fatty acids and amino acids, synthesis of fatty acids, phospholipids, sphingolipids, cholesterol and steroid hormones, synthesis of heme and the neurotransmitter acetylcholine and involved in regulation of gene expression and in signal transduction.