"Other Essentials"

Supplier: Stemcell Technologies

Dulbecco’s phosphate-buffered saline (D-PBS) can be used as a temporary diluting, washing, irrigating or transporting solution for cell or tissue culture. It provides a buffering system to maintain the physiological pH range and osmotic balance of culture media and provides cells with a source of water and essential inorganic ions.

Supplier: Biotium

MTS, TS and maleimide, and other thiol-modifying reagents and reactive fluorescent dyes.

Supplier: Abcam

Anti-KMT2B/MLL4 C-terminal antibody [EPR27970-7] is a Rabbit Monoclonal antibody that is used in KMT2B/MLL4 ChIP-seq, Dot Blot, Western Blot. Suitable for Human, Mouse, Rat samples. KMT2B (MLL4) is a histone methyltransferase that specifically methylates histone H3 at lysine 4 (H3K4), playing a key role in gene regulation. It is involved in chromatin remodeling and is essential for the regulation of developmental genes and stem cell differentiation. Mutations in KMT2B have been linked to various cancers and developmental disorders.

Supplier: Abnova

This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the IKBKG protein, and the other against the specific S31 phosphorylated site of IKBKG for use in Proximity Ligation Assay

Supplier: ROBU GLASFILTER

ROBU® Filter Crucibles with intergrated VitraPOR® filter provide efficient filtration for laboratory applications. Made from durable materials, these crucibles are designed for high-performance filtration, offering reliable separation of solids and liquids. Ideal for gravimetric analysis and other precise filtration processes.

Supplier: Abcam

Anti-HIRA/HIR antibody [EPR25299-11] is a Rabbit Monoclonal antibody that is used in HIRA/HIR IHC-P, IP, Western Blot. Suitable for Human, Mouse, Rat samples. HIRA (Histone Cell Cycle Regulator) is a histone chaperone that facilitates replication-independent chromatin assembly by placing the variant histone H3.3 into nucleosomes. It plays a crucial role in the formation of senescence-associated heterochromatin foci (SAHF), which are involved in the irreversible cell cycle changes in senescent cells. Additionally, HIRA is essential for the periodic repression of histone gene transcription during the cell cycle.

Supplier: Bioss

ADCK2 (aarF domain containing kinase 2), also known as AARF, is a 626 amino acid single-pass membrane protein belonging to the protein kinase superfamily and the ADCK protein kinase family. The ADCK family consists of five paralogs in human (ADCK1-5). Encoded by a gene that maps to human chromosome 7q34, ADCK2 contains one protein kinase domain. ADCK2 participates in ATP and nucleotide binding, transferase functions and protein serine/threonine kinase activities. Expression of ADCK2 inversely correlates with cellular viability, suggesting elevated expression of ADCK2 may be essential for tumour survival. ADCK2 is necessary for cell proliferation of glioblastoma multiforme (GBM), a fatal primary brain tumor containing countless genetic and epigenetic alterations.

Supplier: Bioss

ADCK2 (aarF domain containing kinase 2), also known as AARF, is a 626 amino acid single-pass membrane protein belonging to the protein kinase superfamily and the ADCK protein kinase family. The ADCK family consists of five paralogs in human (ADCK1-5). Encoded by a gene that maps to human chromosome 7q34, ADCK2 contains one protein kinase domain. ADCK2 participates in ATP and nucleotide binding, transferase functions and protein serine/threonine kinase activities. Expression of ADCK2 inversely correlates with cellular viability, suggesting elevated expression of ADCK2 may be essential for tumour survival. ADCK2 is necessary for cell proliferation of glioblastoma multiforme (GBM), a fatal primary brain tumor containing countless genetic and epigenetic alterations.

Supplier: FUJIFILM WAKO CHEMICALS

Monothioglycerol (MTG) can be used as an alternative for 2-mercaptoethanol (2ME) since it exhibits comparable performance to 2ME when it is added to a medium in the culture of mouse ES D3 strain cells.

Supplier: Abcam

Anti-CD3D+CD3G+CD3 epsilon antibody [RM1128] is a Rabbit Recombinant Multiclonal antibody that is used in CD3D+CD3G+CD3 epsilon Flow Cytometry (Intra), ICC/IF, IHC-P, IP, Western Blot. Suitable for Human, Mouse, Rat samples. CD3 is a protein complex found on T cells that is essential for T-cell receptor signaling and activation. In cancer research, CD3-targeted therapies, such as bispecific antibodies, are used to engage T cells and enhance their ability to recognize and destroy tumor cells. This approach has shown promise in treating various cancers, including both hematologic and solid malignancies.

Supplier: Cayman Chemical

TAK-242 ≥98%

Supplier: Portwest

This hardwearing contrast colour jacket is made of 60% cotton and 40% polyester. The soft handle cotton rich fabric is built to last and will look and feel great. Cotton ensures it washes well at 60 °C whilst the polyester gives a ruggedness essential for daily use.

Supplier: Stemcell Technologies

Hanks’ Balanced Salt Solution (HBSS) can be used for diluting, washing, irrigating or as a transporting solution for cell or tissue culture. It provides a buffering system to maintain the physiological pH range and osmotic balance of culture media, and provides cells with a source of water and essential inorganic ions and a carbohydrate as an energy source. Selection of suitable nutrient medium is dependent on type of cell, culture conditions, and degree of chemical definition required for the cell culture application.

Supplier: Stemcell Technologies

Hanks’ Balanced Salt Solution (HBSS) can be used for diluting, washing, irrigating or as a transporting solution for cell or tissue culture. It provides a buffering system to maintain the physiological pH range and osmotic balance of culture media, and provides cells with a source of water and essential inorganic ions and a carbohydrate as an energy source. Selection of suitable nutrient medium is dependent on type of cell, culture conditions, and degree of chemical definition required for the cell culture application.

Supplier: Cytiva

Capto™ HiRes Q and Capto™ HiRes S are prepacked columns for high-resolution purification of proteins and other biomolecules by ion exchange chromatography. They are well-suited for the preparation of highly pure proteins for structural studies and for protein analysis.

Supplier: Biosensis

FUNCTION: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. SUBCELLULAR LOCATION: Cytoplasm. Colocalizes with nonmuscle actin. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. INDUCTION: By apoptotic stimuli. PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane. SIMILARITY: Belongs to the ATG5 family.