Supplier: Charles River Laboratories Cell Solutions

CD4⁺/CD25⁺ regulatory T cells were isolated from leukapheresis product by CD127 depletion and positive selection using CD25 immunomagnetic beads. Peripheral blood cells are collected from normal human volunteers by direct collection or by using the COBE® Spectra or Spectra Optia® Apheresis System where cell-rich leukapheresis product is extracted using continuous flow centrifugal technology directly into the collection bag.

Supplier: Charles River Laboratories Cell Solutions

Human mononuclear cells are isolated from IRB-consented volunteer donors diagnosed with HIV or AIDS.

Supplier: Charles River Laboratories Cell Solutions

Mononuclear cells used for researching the causes, diagnosis, supportive care and treatment of Diabetes Mellitus 2 (DM2), the most common form of diabetes. Human mononuclear cells are collected from human volunteer donors diagnosed with DM2 under IRB approved informed consent by whole blood or leukapheresis using the COBE® Spectra Apheresis System MNC collection protocol.

Supplier: Charles River Laboratories Cell Solutions

Human peripheral blood plasma used for researching the causes, diagnosis, supportive care and treatment of Crohn's disease (CD). Collected from IRB-consented donors diagnosed with CD.

Supplier: Charles River Laboratories Cell Solutions

Human mononuclear cells, rheumatoid arthritis (RA)

Supplier: Charles River Laboratories Cell Solutions

Human serum, systemic lupus erythematosus (SLE)

Supplier: Charles River Laboratories Cell Solutions

The mononuclear cell is a widely used product in research and clinical applications such as in microbiology, virology, oncology, vaccine development, transplant and regenerative biology, and toxicology.

Supplier: Charles River Laboratories Cell Solutions

CD3⁺ T cells are isolated from mononuclear cells by positive selection using immunomagnetic cell separation procedures.

Supplier: Charles River Laboratories Cell Solutions

Neutrophils are derived from a dextran red cell sedimented population of cells. Following red cell sedimentation, granulocytes are separated using a density gradient and red cell lysis. Cells are then purified through the use of indirect selection.

Supplier: Charles River Laboratories Cell Solutions

Mononuclear cells used for researching the causes, diagnosis, supportive care and treatment of chronic myeloid leukemia (CML). Human mononuclear cells are collected from human volunteer donors diagnosed with CML under IRB approved informed consent.

Supplier: Charles River Laboratories Cell Solutions

Serum used for researching the causes, diagnosis, supportive care and treatment of acute myeloid leukemia (AML). Serum is collected from IRB-consented volunteer donors diagnosed with acute myeloid leukemia (AML).

Supplier: Charles River Laboratories Cell Solutions

Human peripheral blood plasma used for researching the causes, diagnosis, supportive care and treatment of type 2 diabetes mellitus (DM 2). Collected from IRB-consented donors diagnosed with type 2 diabetes mellitus.

Supplier: Charles River Laboratories Cell Solutions

Human peripheral blood plasma used for researching the causes, diagnosis, supportive care and treatment of herpes simplex virus 2 (HSV 2). Collected from IRB-consented donors diagnosed with HSV 2.

Supplier: Charles River Laboratories Cell Solutions

CD56⁺ NK cells are isolated from mononuclear cells either by positive selection using an antibody that targets the CD56 antigen, or by negative selection using immunomagnetic cell separation procedures.

Supplier: Charles River Laboratories Cell Solutions

Human serum used for researching the causes, diagnosis, supportive care and treatment of human immunodeficiency virus (HIV). Collected from IRB-consented donors diagnosed with HIV.

Supplier: Charles River Laboratories Cell Solutions

CD34⁺ cells are isolated using positive immunomagnetic cell separation procedures from umbilical cord blood. Human cord blood is collected aseptically at the time of delivery from healthy pregnant women under institutional review board (IRB) approved procedures.

Supplier: Charles River Laboratories Cell Solutions

CD34 depleted mononuclear cells from mobilised peripheral blood are isolated by depleting the CD34 cells using immunomagnetic anti-CD34 microbeads.

Supplier: Charles River Laboratories Cell Solutions

Bone marrow is a major source of stem cells, which are being used in cancer research, cell studies, transplantation studies, and other research.

Supplier: Charles River Laboratories Cell Solutions

Mesenchymal stem cells (MSC) are cultured from freshly collected adult human bone marrow. MSCs are isolated by adherence from bone marrow mononuclear cells, isolated using a density gradient. Adherent cells were cultured in MEM-alpha, supplemented with L-glutamine and Human Platelet Lysate. Bone marrow aspirate is collected from healthy human volunteer donors under IRB approved informed consent and drawn from the posterior iliac crest using a syringe containing anticoagulant.

Supplier: Charles River Laboratories Cell Solutions

Human peripheral blood M2 macrophages are derived from purified monocytes. CD14⁺ monocytes were positively selected via immunomagnetic beads and were cultured in the presence of M-CSF for 10 days. The M2 phenotyping was confirmed by morphology and the expression of specific biomarkers which monitored by flow cytometry. The cells were harvested after 10 days of in vitro culture.

Supplier: Charles River Laboratories Cell Solutions

Human mononuclear cells, multiple myeloma

Supplier: Charles River Laboratories Cell Solutions

Human serum, chronic lymphocytic leukemia (CLL)

Supplier: Charles River Laboratories Cell Solutions

Ulcerative colitis (UC) is isolated from mononuclear cells collected from IRB-consented donors diagnosed with ulcerative colitis (UC).

Supplier: Charles River Laboratories Cell Solutions

Dendritic cells are obtained from a leukapheresis product using immunomagnetic separation techniques.

Supplier: Charles River Laboratories Cell Solutions

CD34⁺ cells are isolated using positive immunomagnetic cell separation procedures from bone marrow. Bone marrow aspirates and cells, drawn from the posterior iliac crest using a syringe containing anticoagulant, are collected from normal human volunteers using institutional review board (IRB) approved procedures.

Supplier: Charles River Laboratories Cell Solutions

Plasma used for researching the causes, diagnosis, supportive care and treatment of ulcerative colitis (UC). Collected from IRB-consented volunteer donors diagnosed with UC.

Supplier: Charles River Laboratories Cell Solutions

Human serum, lung cancer

Supplier: Charles River Laboratories Cell Solutions

Human serum used for researching the causes, diagnosis, supportive care and treatment of multiple sclerosis (MS). Collected from IRB-consented donors diagnosed with MS.

Supplier: Charles River Laboratories Cell Solutions

Mononuclear cells (MNCs) used for researching the causes, diagnosis, supportive care and treatment of Hepatitis C Virus (HCV). Human mononuclear cells are collected from human volunteer donors diagnosed with Hepatitis C virus under IRB approved informed consent.

Supplier: Charles River Laboratories Cell Solutions

Human peripheral blood plasma used for researching the causes, diagnosis, supportive care and treatment of chronic myeloid leukemia (CML). Collected from IRB consented chronic myeloid leukemia (CML) disease donors.