Plasmid+® Media

Plasmid+® Enriched Media is an optimised microbial growth medium formulated to drive high-copy plasmid production with clean downstreams. When paired with Ultra Yield® Flasks and AirOtop® closures, customers have reported plasmid yield increases of up to 610%.

• Optimised formulation for E. coli growth and high-copy plasmids

• Supports low endotoxin output to reduce downstream cleanup
• Consistent, reproducible results across culture runs
• Works on standard orbital shakers from bench to pilot volumes

The Ultra Yield® System combines Ultra Yield® Flasks, AirOtop® Enhanced Seals/Vented Caps, and Plasmid+® Enriched Media to boost microbial productivity - especially E. coli - for plasmid DNA and protein expression. Across customer studies, the system has achieved 85%+ supercoiled plasmid DNA with very low endotoxin, delivered 4–10× material cost savings with about 50% less FTE time, and shown roughly 10× higher aeration with smooth scalability from 125 ml to 2.5 L. Bidirectional Transfer Caps on 1.5/2.5 L flasks further streamline sterile harvests or transfers to larger fermenters.