Leptomycin B
Leptomycin B
Supplier: Abcam
Potent inhibitor of CRM-1-mediated (exportin-1) nuclear export. Displays antibiotic, antifungal, and antitumor properties and blocks the cell cycle at G₁ and G₂ phases. Potent inhibitor of nucleo-cytoplasmic translocation of Rev. Also shown to suppress HIV-1 replication in human monocytes (IC₅₀ = 600 pM).
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Leptomycin B
Supplier: Apollo Scientific
Potent inhibitor of nuclear export.
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