2860 Results for: "Tonbo Biosciences"

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L) - Affinity Pure, min x w/bovine, goat, human, rabbit or rat IgG

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L) - F(ab')2 fragment, Biotin Conjugate, min x w/bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)

Supplier: Tonbo Biosciences

Donkey anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/mouse IgG or serum proteins

Supplier: Tonbo Biosciences

Rabbit anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human, mouse, or rat IgG

Supplier: Tonbo Biosciences

Donkey anti-Goat IgG (H&L) - Affinity Pure, Biotin Conjugate, min x w/human, mouse, rabbit or rat IgG

Supplier: Tonbo Biosciences

Goat anti-Human IgG Fc, F(ab')2 Fragment - Affinity Pure, HRP Conjugate, min x w/bovine, horse, mouse or rabbit serum proteins

Supplier: Tonbo Biosciences

Rabbit anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

Rabbit anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human serum proteins

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/bovine, human, or mouse IgG

Supplier: Tonbo Biosciences

Rabbit anti-Mouse IgG (H&L) - Affinity Pure

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG2b, secondary antibody, conjugated to SureLight® R-Phycoerythrin

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L), F(ab')2 Fragment - Affinity Pure, FITC Conjugate

Supplier: Tonbo Biosciences

Goat anti-Chicken IgY (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

Goat anti-mouse IgG (H+L), secondary antibody, SureLight® R-Phycoerythrin, 100ug

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L), F(ab')2 Fragment - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

Donkey anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

The HI100 antibody reacts with the human CD45 isoform known as CD45RA, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RB, CD45RO and others.

Supplier: Tonbo Biosciences

The 2D1 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and CD45RO.

Supplier: Tonbo Biosciences

The MP4-25D2 antibody is specific for human IL-4, a pleiotropic cytokine that Th2 cell differentiation, B cell proliferation and differentiation, and B cell class switching to IgE. MP4-25D2 is a neutralizing antibody and is reported to cross react with rhesus monkey IL-4.

Supplier: Tonbo Biosciences

The BM8.1 antibody is specific for mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. F4/80 is differentially expressed during myeloid cell development, and may be regulated by certain cytokines within the tissue microenvironment. Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets. BM8.1 is widely used together with antibodies to CD115 (c-fms), CD11b and CD11c to identify myeloid / macrophage cells by flow cytometry.

Supplier: Tonbo Biosciences

The A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin binds to TNP (trinitrophenol), a hapten not expressed on mouse or human cells. It is used as an isotype control for rat IgG2a antibodies.

Supplier: Tonbo Biosciences

The PIP immunoglobulin is useful as an isotype-matched control. The PIP immunolglobulin is specific for Glutathione S-transferase and can be used as an isotype control for Armenian Hamster IgG antibodies.

Supplier: Tonbo Biosciences

The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

Supplier: Tonbo Biosciences

The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.

Supplier: Tonbo Biosciences

The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.

Supplier: Tonbo Biosciences

The UCHT1 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognise antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

Supplier: Tonbo Biosciences

The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.

Supplier: Tonbo Biosciences

The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

Supplier: Tonbo Biosciences

The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17 kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling.