2860 Results for: "Tonbo Biosciences"

Supplier: Tonbo Biosciences

Goat anti-Human IgM (mu chain) - Affinity Pure, min x w/human IgA + IgG

Supplier: Tonbo Biosciences

Goat anti-Human IgA (alpha chain) - Affinity Pure, Biotin Conjugate, min x w/bovine, mouse, and rabbit serum proteins

Supplier: Tonbo Biosciences

Goat anti-Mouse IgM (mu chain) - Affinity Pure, FITC Conjugate

Supplier: Tonbo Biosciences

Goat anti-Mouse IgM (mu chain) - Affinity Pure, FITC Conjugate, min x w/human IgG or serum proteins

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L) - Affinity Pure

Supplier: Tonbo Biosciences

Donkey anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human, mouse, rabbit or rat IgG

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, min x w/ human, mouse or rat serum

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/bovine, human, or mouse IgG

Supplier: Tonbo Biosciences

Rabbit anti-Human IgM (mu chain) - Affinity Pure

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, min x w/ bovine, goat, human, mouse or rat IgG or serum

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/ bovine, goat, human, mouse or rat IgG or serum

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, Biotin Conjugate, min x w/ human, mouse or rat serum

Supplier: Tonbo Biosciences

Rabbit anti-Mouse IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/human serum proteins

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, Biotin Conjugate, min x w/bovine, human, or mouse IgG

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L), F(ab')2 Fragment - Affinity Pure, FITC Conjugate, min x w/ bovine, human, or mouse IgG or serum proteins

Supplier: Tonbo Biosciences

Donkey anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG

Supplier: Tonbo Biosciences

The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will compete for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.

Supplier: Tonbo Biosciences

Goat anti-Rabbit IgG (H&L) - Affinity Pure, Alkaline Phosphatase Conjugate

Supplier: Tonbo Biosciences

Donkey anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

Goat anti-Rat IgG (H&L) - Affinity Pure, HRP Conjugate

Supplier: Tonbo Biosciences

Goat anti-Human IgM (mu chain) - Affinity Pure, min x w/human IgG; bovine, goat, mouse or rabbit serum proteins

Supplier: Tonbo Biosciences

Goat anti-Human IgA (alpha chain), F(ab')2 Fragment - Affinity Pure, FITC Conjugate

Supplier: Tonbo Biosciences

Goat anti-Human IgA (alpha chain), F(ab)'2 Fragment - Affinity Pure, Biotin Conjugate

Supplier: Tonbo Biosciences

The M5/114.15.2 antibody reacts with mouse MHC Class II alloantigens I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek, as well as being cross-reactive with mouse cells of H-2p and H-2r haplotype. MHC Class II is widely expressed by mouse immune cells bearing these alloantigens, including T and B cells, monocytes, macrophages, and dendritic cells. The antibody does not react with the following alloantigens: I-Af, I-Ak, I-As, or NOD H-2g7. The M5/114.15.2 antibody may be used for analysis of mouse cells expressing MHC Class II alloantigens as described. Please note that the M5/114.15.2 clone may also be referred to as M5/114 in the literature.

Supplier: Tonbo Biosciences

The L243 antibody reacts with a member of the human MHC Class II antigens, HLA-DR. The HLA-DR antigen is expressed on B lymphocytes, activated T lymphocytes, activated NK cells, monocytes, macrophages, other antigen presenting cells and progenitor cells. The L243 antibody is specific to an epitope on the alpha subunit of the heterodimeric HLA-DR protein and binds a different epitope than the LN3 antibody clone. It does not cross-react with HLA-DP or HLA-DQ. This antibody is reported to be cross-reactive with non-human primates including Chimpanzee, Cynomolgus, Rhesus and Baboon. Please choose the appropriate format for each application.

Supplier: Tonbo Biosciences

The L243 antibody reacts with a member of the human MHC Class II antigens, HLA-DR. The HLA-DR antigen is expressed on B lymphocytes, activated T lymphocytes, activated NK cells, monocytes, macrophages, other antigen presenting cells and progenitor cells. The L243 antibody is specific to an epitope on the alpha subunit of the heterodimeric HLA-DR protein and binds a different epitope than the LN3 antibody clone. It does not cross-react with HLA-DP or HLA-DQ. This antibody is reported to be cross-reactive with non-human primates including Chimpanzee, Cynomolgus, Rhesus and Baboon. Please choose the appropriate format for each application.

Supplier: Tonbo Biosciences

The 2H7 antibody reacts with human CD20, expressed by pre-B cells, resting and activated B cells, follicular dendritic cells and a small subset of T cells, but not on plasma cells. CD20 is a 33-37 kDa transmembrane protein which is differentially phosphorylated in resting and active B cells. The CD20 molecule plays a role in regulating B-cell activation. The 2H7 antibody is reported to be cross-reactive with several non-human species including Baboon, Chimpanzee, Cynomolgus and Rhesus. Please choose the appropriate format for each application.

Supplier: Tonbo Biosciences

The ICRF44 antibody reacts with human CD11b, also known as integrin alpha M. This 165 to 170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1, ICAM-2, ICAM-3 and ICAM-4 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

Supplier: Tonbo Biosciences

The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells.