"Stemcell Technologies"

Supplier: Stemcell Technologies

Medium for preparing and washing samples for colony-forming unit (CFU) assays.

Supplier: Stemcell Technologies

Methylcellulose-based medium with recombinant cytokines (without EPO). 24×3 ml vials.

Supplier: Stemcell Technologies

Immunomagnetic negative isolation of untouched CD4+ T cells from leukopaks.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, chimpanzee CD73, unconjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b antibody against human CD235ab (glycophorin A/B), unconjugated.

Supplier: Stemcell Technologies

Rat monoclonal antibody against human IL-4, unconjugated.

Supplier: Stemcell Technologies

Myeloma and hybridoma culture medium (serum-containing).

Supplier: Stemcell Technologies

Immunomagnetic isolation of untouched human hematopoietic progenitors

Supplier: Stemcell Technologies

Serum-free media for generation and maturation of branching lung organoids from human ES and iPS cells.

Supplier: Stemcell Technologies

Complete kit for optimisation of genome editing in human cells.

Supplier: Stemcell Technologies

Vascular endothelial growth factor (VEGF-121) is a naturally-occurring VEGF-A splice variant involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 and VEGFR-2, and activates Raf/MEK/ERK and PI3K/AKT pathways. VEGF-121 is released as a freely diffusible protein by a variety of normal and transformed cells. It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum et al.). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara et al.).

Supplier: Stemcell Technologies

R-Spondin-1 (RSPO1) is the prototype member of the R-Spondin (RSPO) protein subfamily of a superfamily of thrombospondin type 1 repeat (TSR-1)-containing proteins (Chen et al.; Kamata et al.; Kazanskaya et al.; Kim et al.). Although unable to initialize signaling, RSPO family members are potent enhancers of WNT signaling (Cruciat and Niehrs; de Lau et al.; Kamata et al.; Kazanskaya et al.). They are characterized by a TSR-1 domain, a carboxy-terminal region with positively charged amino acids, and two N-terminal furin-like cysteine-rich repeats (Glinka et al.; Kazanskaya et al.). R­-Spondin-1 activates β­-catenin signaling via the WNT signaling cascade and by indirectly increasing low-density lipoprotein receptor-related protein 6 (LRP6) on the cell surface. It does this by binding leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), and competing with WNT antagonist DKK­1 for binding to the WNT co­receptors, Kremen and LRP­6, which reduces DKK­1-­mediated internalization of LRP6 (Binnerts et al.). RSPO1 is involved in a wide range of pleiotropic roles during embryogenesis, it is required for the specification of hematopoietic stem cells, and it has been shown to be important in the growth, survival, and migration of ovarian cancer cells (Cruciat and Niehrs; de Lau et al.; Genthe and Clements; Liu et al.).

Supplier: Stemcell Technologies

The principal physiological regulator of erythropoiesis, Erythropoietin (EPO) is a glycoprotein growth factor that is produced primarily in the kidney in response to hypoxia or anemia. EPO promotes erythropoiesis by binding to a homodimeric cell surface receptor that activates JAK2/STAT5, PI3K/AKT, and MAPK pathways, and stimulates the proliferation and differentiation of erythroid progenitor cells (Jelkmann. Transfus Med Hemother, 2013; Kuhrt and Wojchowski. Blood, 2015).

Supplier: Stemcell Technologies

Amine-labelling fluorescent dye for live/dead staining of mammalian cells - 100 tests.

Supplier: Stemcell Technologies

Influenza (HLA class I control) peptide pool is a lyophilised mixture of 17 peptides from the influenza virus. The pool consists of defined HLA class I-restricted T cell epitopes, and can be used as an antigen-specific positive control to stimulate T cells.

Supplier: Stemcell Technologies

Rat monoclonal IgG2a antibody against mouse CD150 (SLAM), APC-conjugated.