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Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterise amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). 60019-2-Ig is a mouse monoclonal antibody recognizing the cleavage product of 20-30 kDa in addition to the native and phosphorylated forms of TDP-43. Immunohistochemical analyses of TDP-43 using this antibody detect both normal diffuse nuclear staining and insoluble inclusions in pathologic tissues. The epitope of 60019-2-Ig has been determined to locate at residues 203-209 by Hiroshi Tsuji et al. (2012), which is involved in the formation of pathologic TDP-43 aggregation. Notably this antibody only recognizes human TDP-43 but not reacts with mouse or rat TDP-43.

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Human β-site APP-Cleaving Enzyme 1 (BACE1) ELISA Kit

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Human C-C motif chemokine 27 (CCL27) ELISA Kit

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Dog Interleukin-5 (IL5) ELISA Kit

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Human Leukocyte Antigen C (HLA-C) ELISA Kit

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Human Soluble Receptor Activator of Nuclear Factor-kB, sRANK ELISA Kit

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Human Elastase 1, pancreatic (ELA1) ELISA Kit

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Human Guanine nucleotide-binding protein G (GNB1) ELISA Kit

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Human Inhibin A (INH-A) ELISA Kit

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Rat Estradiol receptor (ER) ELISA Kit

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Human Actin like protein 7A (ACTL7A) ELISA Kit

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Human T-complex protein 1 subunit epsilon (CCT5) ELISA Kit

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Mouse Beta-Hydroxybutyric Acid (β-OHB) ELISA Kit

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Human Protein Wnt-10b (WNT10B) ELISA Kit

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Mouse Nephronectin (NPNT) ELISA Kit

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Rat Pancreatic Lipase (PL ) ELISA Kit