10503 Results for: "ENZO LIFE SCIENCES"
Human recombinant MMP-14 (catalytic domain) (112-298)
Supplier: Enzo Life Sciences
Produced in E.coli. Active Matrix Metalloproteinase-14 (MMP-14, Membrane-Type Matrix Metalloproteinase 1, MT1-MMP) catalytic domain from human cDNA.
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Human recombinant SIRT2 (from E. coli), His-tag
Supplier: Enzo Life Sciences
Produced in E. coli. Contains a N-terminal His-tag.
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Ubiquitin-AMC
Supplier: Enzo Life Sciences
High purity industry standard substrate for deubiquitinylating enzymes (DUBs).
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Why Choose Corning Fetal Bovine Serum?
Our vertically integrated FBS serum supply chain, from collection to scientist, allows us to provide a consistent supply of FBS.
Human recombinant Granzyme B (from yeast)
Supplier: Enzo Life Sciences
Produced in yeast. Recombinant human granzyme B (aa 21-247).
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Phorbol-12,13-dibutyrate ≥99% (by HPLC)
Supplier: Enzo Life Sciences
Widely used PKC activator (10 to 100 ng/ml).
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Anti-Proteinase-Activated Receptor-4 Rabbit Polyclonal Antibody
Supplier: Enzo Life Sciences
PAR-4 belongs to a four member family of G protein-coupled receptors (PAR-1 to -4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this modality of activation, a specific proteinase cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This cleavage results in the creation of a new N-terminal sequence (tethered ligand), which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways1-3 Different PARs are activated by different proteinases. PAR-4 is activated by both thrombin and trypsin whereas PAR-1 and PAR-3 are activated by thrombin and PAR-2 is activated by trypsin1-3. PAR-4 can be also cleaved and activated by other proteinases such as cathepsin G. The intracellular signaling mechanisms mediated by PAR-4 activation are not completely elucidated but they may involve calcium mobilization downstream of phospholipase C through the Gαq pathway1-3 Tissue distribution of PAR-4 is very broad with the highest expression levels found in lung, testis, pancreas and small intestine. In addition, PAR-4 expression was observed in platelets, megakaryocytes and leukocytes. Studies with platelets derived form PAR-4 knockout mice have established an essential role for PAR-4 in thrombin-induced platelet activation.PAR-4 is likely involved in other physiological functions such as regulation of gastrointestinal motility and regulation of vascular endothelial cell function1-3.
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Anti-KLK2 Rabbit Polyclonal Antibody
Supplier: Enzo Life Sciences
Host: Rabbit
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Anti-BACE1 Rabbit Polyclonal Antibody
Supplier: Enzo Life Sciences
BACE1 is expressed as a pre-pro-aspartyl protease, sometimes glycosylated, and inserted into the cell membrane as a dimer with catalytic domains in the cytosol. It is implicated in angiogenesis and Alzheimer’s disease.
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Anti-14-3-3 zeta Rabbit Polyclonal Antibody
Supplier: Enzo Life Sciences
Host: Rabbit
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[beta-Ala8]Neurokinin A (4-10)
Supplier: Enzo Life Sciences
Neurokinin receptor ligand
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Nicotinamide
Supplier: Enzo Life Sciences
Nicotinamide, the water-soluble amide of nicotinic acid, is a component of the two most important coenzymes-nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Nicotinamide is involved in numerous oxidation-reduction reactions in mammalian biological systems acting as an antioxidant.
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Fluor-de-Lys® Developer II concentrate
Supplier: Enzo Life Sciences
FLUOR DE LYS® Developer II is an essential reagent for signal generation in assays done with the FLUOR DE LYS®-HDAC8, FLUOR DE LYS®-SIRT1 and FLUOR DE LYS®-SIRT2 substrates. Deacetylation of the FLUOR DE LYS® substrate sensitises it so that, in a second step, treatment with the FLUOR DE LYS® Developer II produces a fluorophore. Typically, an ‘inhibitor stop’ will be included in the 1X Developer dilution (e.g. nicotinamide for sirtuins).
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FLUOR DE LYS®-succinyl green, desuccinylase substrate 5 mM in DMSO (synthetic) , 95% (by HPLC)
Supplier: Enzo Life Sciences
The FLUOR DE LYS®-Succinyl green, desuccinylase substrate offers a highly sensitive and convenient alternative to radiolabeled, succinylated histones or peptide/HPLC methods for the assay of desuccinylases such as SIRT5.
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EGTA (2X) Buffer, Enzo Life Sciences
Supplier: Enzo Life Sciences
EGTA buffer, 2X
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Batrachotoxin ≥90% (by HPLC, TLC)
Supplier: Enzo Life Sciences
Na+ channel activator
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Anti-HERG2 Rabbit Polyclonal Antibody
Supplier: Enzo Life Sciences
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
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Anti-P2X4 Rabbit Polyclonal Antibody
Supplier: Enzo Life Sciences
Host: Rabbit
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Human recombinant IGF-I (from E. coli)
Supplier: Enzo Life Sciences
Human recombinant IGF-I (from E. coli)
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Anti-LAMP2 Rat Monoclonal Antibody
Supplier: Enzo Life Sciences
Lysosome-associated membrane proteins (LAMP1 and LAMP2) are type I integral membrane protein that are transported from the trans-Golgi network to endosomes and then lysosomes. Following activation of platelets, T-cells, neutrophils, or endothelium, LAMP1 and LAMP2 are expressed on the cell surface. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and loss of LAMP2 expression is associated with impaired autophagy observed in Danons disease.
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25(OH) Vitamin D ELISA kit
Supplier: Enzo Life Sciences
Rapid, easy-to-use ELISA kit to quantify 25(OH) Vitamin D for bone metabolism, nutrition, endocrinology, immunity and cancer.
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Mouse-HRP/rabbit-AP IHC, MULTIVIEW®
Supplier: Enzo Life Sciences
Mouse-HRP/rabbit-AP IHC is a biotin-free one-step detection system suitable for demonstrating antigens in formalin-fixed paraffin-embedded tissues and cryostat sections.
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Anti-IgG2a Mouse Monoclonal Antibody (DyLight® 488)
Supplier: Enzo Life Sciences
Isotype matched controls are useful in flow cytometry to determine a gross estimate of non-specific binding that may be observed with a specific antibody of interest. In general, an isotype control should be of the same species and isotype as the antibody of interest, used at the same concentration, and conjugated to the same fluorophore. This reagent is an IgG2a isotype mouse monoclonal antibody (Clone # C1.18), conjugated to DyLight™-488. It is intended for use as an isotype control antibody for flow cytometry.
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Necrostatin-1 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Inhibits necroptosis
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Cyclo [Arg-Gly-Asp-D-Phe-Val]
Supplier: Enzo Life Sciences
Integrin αvβ3 antagonist. Inhibits cell adhesion events mediated by αvβ3. Inhibits angiogenesis. Induces rapid regression of histologically distinct human tumors. Induces apoptosis of angiogenic blood vessels.