10503 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

This sequence, RRKDLHDDEEDEAMSITA, is derived from inhibitor-2 of protein phosphatase-1 with changes that make it an excellent substrate for casein kinase I (Km=172 µM), while rendering it a poor substrate for casein kinase II.

Supplier: Enzo Life Sciences

Produced in Sf9 cells. Recombinant full length MKP-1.

Supplier: Enzo Life Sciences

Selective inhibitor of sFRP-1

Supplier: Enzo Life Sciences

Highly sensitive ApoE ELISA kit enabling detection of ApoE in serum, plasma, cell culture supernates, and tissue homogenates in 3,5 hours.

Supplier: Enzo Life Sciences

Highly sensitive Peptide YY ELISA kit enabling detection of PYY in serum in 3,5 hrs.

Supplier: Enzo Life Sciences

P62, also known as Sequestosome I, is a 62kDa, 440 amino acid protein, initially identified as a ligand of the SH2 domain of p56lck, now known to be expressed in many tissues. In addition to TRAF6, PEST and zinc finger motifs, p62 has a C-terminal ubiquitin binding association (UBA) domain with an affinity for multi-ubiquitin chains, and it is considered to serve as a scaffold protein, capable of binding to multiple signalling molecules and uniting receptor-mediated signalling events with ubiquitinylation. Elevated levels of p62 have been reported in breast tumours and in alcoholic liver disease where p62 has been shown to be involved in the formation of Mallory bodies. Several mutations in the p62 UBA domain have been identified and the etiology of Paget’s disease of bone has been linked to one such mutation. Kuusisto and colleagues have demonstrated that p62 is also present in elevated levels in the hallmark inclusions found in various neurodegenerative conditions, including tauopathies (Alzheimer’s disease, Picks disease, and frontotemporal dementia) and synucleinopathies (Parkinson’s disease, dementia with Lewy body disease and multiple system atrophy). In recent years ubiquitin immunostaining has been used to provide adjunct information for neuropathological diagnosis, but it is becoming evident that p62 may be an even more reliable marker of neurodegenerative disease inclusion detection than tau, alpha-synuclein or ubiquitin immunostaining.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Optimised probe-based qPCR.

Supplier: Enzo Life Sciences

Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.

Supplier: Enzo Life Sciences

RanGEF, also known as regulator of chromosome condensation (RCC1), is an abundant, highly conserved chromatin-associated 45 kDa protein. RanGEF is involved in the regulation of the onset of chromosome condensation in the S phase, and is the principle mammalian guanine nucleotide exchange factor (GEF) for the nuclear G protein Ran. RanGEF plays important roles in RNA transcription and processing, DNA replication, nuclear pore transport function, and cell cycle regulation.

Supplier: Enzo Life Sciences

The DNA damage checkpoint is a signal transduction pathway that has the ability to delay entry into mitosis. When DNA is damaged, the Check point kinases (CHKs) are known to act downstream of ATM to elicit appropriate responses such as cell cycle arrest. Chk1, for instance, is activated by ATM phosphorylation of serines 123, 178, 278, and 292 of the S phase-promoting cdc25A phosphatase and accelerates IR (ionizing radiation)induced degradation of cdc25A.

Supplier: Enzo Life Sciences

p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma.

Supplier: Enzo Life Sciences

Vimentin is one of four type II intermediate filament (IF) proteins; Desmin, Glial fibrillary acidic protein (GFAP) and Peripherin being the others. Vimentin is the most widely distributed of all IF proteins. It is typically expressed in leukocytes, blood vessel endothelial cells, and mesenchymal cells such as fibroblasts. Vimentin filaments help support cellular membranes. Vimentin networks also may help keep the nucleus and other organelles in a defined place within the cell.

Supplier: Enzo Life Sciences

Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.

Supplier: Enzo Life Sciences

For the quantitative determination of [pThr183/Tyr185]Jnk1/2 in cell lysates of human, mouse, and rat origin.

Supplier: Enzo Life Sciences

Potent, cell permeable and ATP-competitive inhibitor of DNA-PK, phosphoinositide 3-kinase (PI(3)K), the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. Exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10µM. Effectively blocks cell proliferation in glioma cell lines both in vitro and in vivo.

Supplier: Enzo Life Sciences

For the quantitative determination of [pThr180/Tyr182]p38 in cell lysates of human and mouse origin.

Supplier: Enzo Life Sciences

PI3 kinase inhibitor

Supplier: Enzo Life Sciences

Highly sensititive ELISA, meausring 8-iso-Prostaglandin F2α in plasma, serum and tissue.

Supplier: Enzo Life Sciences

Isolated from human plasma. Plasminogen depleted.

Supplier: Enzo Life Sciences

Produced in E.coli.

Supplier: Enzo Life Sciences

Linear polyubiquitin chains are useful tools for investigating, amongst other things, the specificity and reactivity of deubiquitinylating enzymes (DUBs) and the recognition and interaction of linear polyubiquitin modified proteins with by ubiquitin binding domain (UBDs) containing proteins.

Supplier: Enzo Life Sciences

Protein components produced in E. coli. Synthesised enzymatically in vitro.

Supplier: Enzo Life Sciences

Heat-labile alkaline phosphatase for dephosphorylation of DNA, RNA and nucleotides

Supplier: Enzo Life Sciences

Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins, members of which possess an overall structure consisting of multiple globular head regions linked by triple-helical, collagen-like, strands. This group also includes SP-D, and the serum proteins mannan-binding protein, conglutinin, and collectin-43, all of which bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/mL in healthy individuals.

Supplier: Enzo Life Sciences

Produced in E. coli. Poly-SUMO-3 chains were synthesized enzymatically using SUMO-3 and purified by size exclusion chromatography to remove SUMO-3 monomer.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli. Human ISG15 E1 is fused at the C-terminus to a His-tag.