Supplier: Bioss

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses.

Supplier: Biotium

5(6)-TAMRA SE (full name: 5-(and-6)-Carboxytetramethylrhodamine succinimidyl ester (mixed isomers)) is the amine reactive form of TAMRA, one of the most commonly used red fluorescent dyes. The succinimidyl ester reacts readily with primary or secondary amines under mild conditions.

Supplier: Bioss

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Supplier: Bioss

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Supplier: Thermo Fisher Scientific

Appearance: Clear colorless to light yellow Liquid

Supplier: Apollo Scientific

N-(tert-Butoxycarbonyl)-1,4-diaminobutane 97%

Supplier: Bioss

Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008].

Supplier: Bioss

TIS11D is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.

Supplier: AAT BIOQUEST

CypHer7E NHS ester is an excellent building block for developing site-specific pH probes.

Supplier: AAT BIOQUEST

XFD594 NHS Ester (Succinimidyl Ester) is the same molecule to the Alexa Fluor® 594 NHS Ester (Alexa Fluor® is the trademark of ThermoFisher).

Supplier: AAT BIOQUEST

Norfentanyl NHS Ester is an excellent amino-reactive building block for developing antibodies, assays and tests for detecting norfentanyl substances.

Supplier: AAT BIOQUEST

Xylazine NHS ester is an excellent amino-reactive building block for developing assays and tests for detecting Xylazine.

Supplier: AAT BIOQUEST

DBCO-Sulfo-NHS Ester is a water-soluble version of the popular DBCO NHS Ester (#4529).

Supplier: AAT BIOQUEST

XFD514 NHS ester]

Supplier: AAT BIOQUEST

XFD532 NHS Ester (Succinimidyl Ester) is the same molecule to the Alexa Fluor® 532 NHS Ester (Alexa Fluor® is the trademark of ThermoFisher).

Supplier: AAT BIOQUEST

XFD594 NHS Ester (Succinimidyl Ester) is the same molecule to the Alexa Fluor® 594 NHS Ester (Alexa Fluor® is the trademark of ThermoFisher).

Supplier: AAT BIOQUEST

XFD350 NHS Ester (Succinimidyl Ester) is the same molecule to the Alexa Fluor® 350 NHS Ester (Alexa Fluor® is the trademark of ThermoFisher).

Supplier: Thermo Fisher Scientific

Azadibenzocyclooctyne-PEG4-NHS ester (ADIBO-PEG4-NHS ester) is applied for protein-peptide conjugation, peptide-small molecule conjugation, 18F radiolabeling, protein-oligonucleotide conjugation and surface modification.

Supplier: AAT BIOQUEST

XFD405 NHS Ester (Succinimidyl Ester) is the same molecule as Alexa Fluor® 405 NHS Ester (#A30000 from ThermoFisher, Alexa Fluor® is the trademark of ThermoFisher).

Supplier: Bioss

This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Supplier: AAT BIOQUEST

RatioWorks™ PH165 NHS ester is a novel fluorescent probe that can be used to measure intracellular pH in live cells.

Supplier: AAT BIOQUEST

XFD660, synthesized by AAT Bioquest, shares the exact same chemical structure with Alexa Fluor® 660 (a ThermoFisher trademark).

Supplier: AAT BIOQUEST

XFD532 NHS Ester (Succinimidyl Ester) is the same molecule to the Alexa Fluor® 532 NHS Ester (Alexa Fluor® is the trademark of ThermoFisher).

Supplier: AAT BIOQUEST

CypHer5E NHS ester is an excellent building block for developing site-specific pH probes.

Supplier: AAT BIOQUEST

XFD488 NHS Ester (Succinimidyl Ester) is the same molecule to the Alexa Fluor® 488 NHS Ester (Alexa Fluor® is the trademark of ThermoFisher).

Supplier: AAT BIOQUEST

QXY7 is the same molecule to QSY-7 acid (ThermoFisher).

Supplier: Bioss

ACADVL (acyl-Coenzyme A dehydrogenase, very long chain) catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. It is specific to esters of long-chain and very long chain fatty acids such as palmitoyl-CoA and stearoyl-CoA. Deficiencies in ACADVL are associated with reduced myocardial fatty acid beta-oxidation and cardiomyopathy.

Supplier: AAT BIOQUEST

XFD750 is manufactured by AAT Bioquest, and it has the same chemical structure of Alexa Fluor® 750 (Alexa Fluor® is the trademark of ThermoFisher).

Supplier: AAT BIOQUEST

Cy2DIGE NHS ester, an equivalent of Cy2® NHS ester minimal dye, is used for labeling proteins subject to DIGE analysis.

Supplier: AAT BIOQUEST

Cyclic adenosine monophosphate (cAMP) is a second messenger used for intracellular signal induction.