783 Results for: "CDK1"

Supplier: Bioworld Technology

Synthetic phosphopeptide derived from human Cdk1/Cdc2 around the phosphorylation site of Serine 795.

Supplier: Abcam

Anti-Cdk1+Cdk2+Cdk3+Cdk5 Rabbit Monoclonal Antibody [clone: EPR2233Y]

Supplier: Abcam

Anti-CDK1+CDK2+CDK3+CDK5 Rabbit Monoclonal Antibody [clone: E53]

Supplier: Abcam

Anti-CDK1 Rabbit Monoclonal Antibody [clone: YE324]

Supplier: Bioworld Technology

Synthetic phosphopeptide derived from human Cdk1/Cdc2 around the phosphorylation site of Serine 795.

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Supplier: US Biological

Anti-CDK1 Mouse Monoclonal Antibody [clone: 1A4-1A9]

Supplier: Abcam

Anti-CDK1 Rabbit Monoclonal Antibody [clone: BLR085G]

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (PE (Phycoerythrin))

Supplier: Biotium

Recognizes a 34 kDa protein, which is identified as cyclin dependent kinase 1 (cdk1) or p34cdc2 protein kinase. cdk1 / p34cdc2 plays a crucial role during cell division and is most active during mitosis. It is predominantly localized in the nucleus. It is a serine/threonine kinase, which is activated by cyclin, presumably by de-phosphorylation of tyrosine residues. Activated cdk1 / p34cdc2 performs specific functions during mitosis, including nuclear envelope breakdown and chromosome condensation.

Supplier: Bioss

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterised of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Supplier: Abcam

Anti-CDK1 (phospho Y15) Rabbit Monoclonal Antibody [clone: BLR101H]

Supplier: Abcam

Anti-CDK1 Rabbit Monoclonal Antibody [clone: YE324]

Supplier: Biotium

Recognizes a 34 kDa protein, which is identified as cyclin dependent kinase 1 (cdk1) or p34cdc2 protein kinase. cdk1 / p34cdc2 plays a crucial role during cell division and is most active during mitosis. It is predominantly localized in the nucleus. It is a serine/threonine kinase, which is activated by cyclin, presumably by de-phosphorylation of tyrosine residues. Activated cdk1 / p34cdc2 performs specific functions during mitosis, including nuclear envelope breakdown and chromosome condensation.

Supplier: Biotium

Recognizes a 34 kDa protein, which is identified as cyclin dependent kinase 1 (cdk1) or p34cdc2 protein kinase. cdk1 / p34cdc2 plays a crucial role during cell division and is most active during mitosis. It is predominantly localized in the nucleus. It is a serine/threonine kinase, which is activated by cyclin, presumably by de-phosphorylation of tyrosine residues. Activated cdk1 / p34cdc2 performs specific functions during mitosis, including nuclear envelope breakdown and chromosome condensation.

Supplier: Abcam

Anti-CDK1+CDK2+CDK3+CDK5 Rabbit Monoclonal Antibody [clone: E53]

Supplier: Abcam

Anti-CDK1 Rabbit Monoclonal Antibody [clone: EPR165] (Alexa Fluor® 750)

Supplier: Abcam

Anti-Cdk1 + Cdk2 (phospho T14) Rabbit Monoclonal Antibody [clone: EPR17499]

Supplier: Bioss

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

Supplier: Bioss

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

Supplier: Bioss

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

Supplier: Bioss

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Competitive inhibitor of CDK1/cyclin B (IC50=5µM) and CDK2/cyclin A (IC50=12µM). Pharmacologically distinct from the relative specific inhibitor of CDK1/2 roscovitine.

Supplier: Abcam

Anti-CDK1 (phospho Y15) Rabbit Polyclonal Antibody

Supplier: Abcam

Anti-CDK1 Rabbit Monoclonal Antibody [clone: EPR165]

Supplier: Bioss

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Supplier: Abcam

Anti-CDK1 Rabbit Monoclonal Antibody

Supplier: Abcam

Anti-Cdk1-2-3-5 Rabbit Monoclonal Antibody [clone: EP762RY]