783 Results for: "CDK1"

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (PE (Phycoerythrin))

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (FITC (Fluorescein))

Supplier: US Biological

Anti-CDK1 Mouse Monoclonal Antibody [clone: POH-1]

Supplier: Abcam

Anti-CDK1 Mouse Monoclonal Antibody [clone: A17.1.1]

Supplier: Bioworld Technology

Synthetic peptide, corresponding to amino acids 771-820 of Human Cdk1/Cdc2.

Supplier: Aviva Systems Biology

Anti-CDK1 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody

Supplier: Abgent

Anti-CDK1 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody

Supplier: Bioss

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Supplier: US Biological

Anti-cdk1, p34cdc2 Mouse Monoclonal Antibody [clone: 5F291]

Supplier: Abcam

Anti-CDK1 Rabbit Monoclonal Antibody [clone: YE324] (APC)

Supplier: Abcam

Anti-CDK1 Mouse Monoclonal Antibody [clone: A17]

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

Supplier: Bioss

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Supplier: Bioss

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Supplier: Bioss

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Supplier: Abcam

Anti-CDK1 Rabbit Monoclonal Antibody [clone: E53]

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Supplier: US Biological

Anti-CDK1 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

Supplier: Bioworld Technology

Synthetic phosphopeptide derived from human Cdk1/Cdc2 around the phosphorylation site of Serine 795.

Supplier: Bioworld Technology

Synthetic phosphopeptide derived from human Cdk1/Cdc2 around the phosphorylation site of Serine 795.

Supplier: Bioworld Technology

Synthetic phosphopeptide derived from human Cdk1/Cdc2 around the phosphorylation site of Threonine 14.

Supplier: Bioss

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Supplier: Bioss

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.