In this experiment, students determine a pedigree for a family thought to be carriers of a mutation in their p53 genes. This is followed by a diagnostic agarose gel analysis to diagnose the state of the p53 gene in individual family members.

• For six lab groups

Also required: Electrophoresis tank, power supply, micropipettes (5 to 50 µl adjustable or 40 µl fixed volume) with tips, and a white light box is recommended.