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Anti-GPCR TGR5/GPBAR1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Anti-GPCR TGR5/GPBAR1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-8874R-A750
Supplier:  Bioss
Anti-GPCR TGR5/GPBAR1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-8874R-A750
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    GPCR TGR5/GPBAR1
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 750
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human
  • Western blot:
    Yes
  • Epitope:
    5-100/330
  • Form:
    Liquid
  • Gene ID:
    151306
  • Antigen synonyms:
    Membrane bile acid receptor|M-BAR|Membrane-type receptor for bile acids|Membrane type receptor for bile acids|hBG 37|GPR131|GPCR 19|G-protein coupled bile acid receptor 1|M BAR|G protein coupled bile acid receptor BG37|hGPCR 19|hBG37|MGC40597|GPBAR1|GPBAR 1|GPCR|G protein coupled bile acid receptor BG 37|G protein coupled bile acid receptor 1|BG 37|TGR5|GPBAR_HUMAN|G-protein coupled receptor GPCR19|BG37|GPR 131|TGR 5|hGPCR19|GPCR19
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Storage temperature:
    Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human GPBAR1
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalisation, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

Type: Primary
Antigen: GPCR TGR5/GPBAR1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 5-100/330
Host: Rabbit
Isotype: IgG
Reactivity: Human