Human Recombinant Follistatin (from E. coli)
Supplier: Shenandoah Biotechnology
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About this item
Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-β) family members, such as activin, bone morphogenetic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-β1. Follistatin functions as an antagonist by binding TGF-β family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary.
- High quality
- Low endotoxin
- Affordable
Caution: For research use only.
Specifications
- Conjugation:Unconjugated
- Protein function:Cytokine
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Storage conditions:–20 °C
- Endotoxin content:Endotoxin LAL (EU/µg) ≤0,1
- Biological activity:Bioactivity Assay: Neutralization of Human Activin A induced cytotoxicity of MPC-11 cells, ED₅₀ ≤200 ng/ml, Bioactivity ≥5,0×10³ units/mg
- Gene ID:P19883
- Reconstitution instructions:Sterile water at 0,1 mg/ml
- Endotoxin-free:N
- Carrier-free:Y
- Protease-free:N
- Animal-free:N
- Protein synonyms:FS|activin-binding protein|FSH-suppressing protein (FSP)
- Protein/peptide name:Follistatin
- Purity:≥95%
- Molecular weight:31,7 kDa
- Sequence:mgNCWLRQAK NGRCQVLYKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRMNKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGRCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPEPASSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCTGGKKCLW DFKVGRGRCS LCDELCPDSK SDEPVCASDNATYASECAMK EAACSSGVLL EVKHSGSCN
- Endotoxin level:Low
- Formulation:10 mM Sodium phosphate, 50 mM Sodium chloride, pH 7,5
- Nuclease-free:N
- Grade:RUO
- Shipping temperature:RT
- Tested applications:Bioassay