CaM kinase inhibitor

Synthetic peptide with sequence from Ca²⁺/calmodulin-dependent protein kinase II pseudosubstrate site. Peptide binds calmodulin tightly and inhibits calmodulin-requiring enzymes including CaMKII, phosphodiesterase and calcineurin. IC50=52 nM for CaMKII in the presence of 100 nM calmodulin.