- Antibody type:Primary
- Antigen name:Vasopressin Receptor 1b
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Western blot:Yes
- Seq:02
- Epitope:near the N-Terminus
- Form:Liquid
- Storage buffer:PBS containing 50% glycerol and 0.01% sodium azide.
- Storage temperature:–20 °C
- Shipping temperature:Shipped on blue ice
- Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of rat vasopressin receptor V1b.
- Purification:purified by peptide affinity chromatography
- Pk:100 µG
Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1), V1b (V3), and V2. V1b receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas. V2 receptors in the collecting ducts of the kidneys stimulate adenylyl cyclase activity, regulating the reabsorption of water via aquaporin channels.
Type: Primary
Antigen: Vasopressin receptor 1b
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: near the N-Terminus
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat