Specifications
- Antibody type:Primary
- Antigen name:NLR family, pyrin domain containing 6
- Antigen symbol:NLRP6
- Clonality:Monoclonal
- Clone:Clint-1
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- Isotype:IgG1 kappa
- Reactivity:Human
- Western blot:Yes
- Form:Liquid
- Gene ID:171389
- Antigen synonyms:Nod-like Receptor Pyrin Domain-containing Protein 6|LRR and PYD Domains-containing Protein 6|Angiotensin II/Vasopressin Receptor|PYRIN-containing APAF1-like Protein 5|NALP6|NLRP6|NACHT-
- Storage buffer:In PBS containing 10% glycerol and 0.02% sodium azide.
- Storage temperature:Stable for at least 1 year after receipt when stored at -20˚C.
- Concentration:1 mg/ml
- Shipping temperature:-20°C
- Immunogen:Recombinant human NLRP6 (NACHT domain).
- Purification:>95% (SDS-PAGE)
- Size:100 μg
- Pk:100 µG
Specifications
About this item
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.
Type: Primary
Antigen: NLRP6
Clonality: Monoclonal
Clone: Clint-1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human