p16^INK4A is cyclin-dependent kinase inhibitors that inhibit cylcin-dependent kinases 4 and 6, it is encoded by tumor suppressor gene CDKN2A. The tumor suppressor p16^INK4A plays an important role in cell cycle regulation.

• Control Tissue: Human cervical cancer, tonsil
• Staining: Cytoplasmic and Nuclear
• Dilution: 1:100 - 1:400 (IHC-cytostat - formalin-fixed, paraffin embedded)

Increased expression of the p16 gene, which is seen as organisms age, reduces the proliferation of stem cells. This reduction in the division and production of stem cells protects against cancer while increasing the risks associated with cellular senescence. Mutations in the p16 gene associated with loss or over expression of the protein are associated with increased risk of a wide range of cancers and cancer precursor lesions. The Immunohistochemical identification of p16 is particularly relevant in uterine cervical lesions: Development of dysplasia is closely related to human papilloma virus (HPV) infection.

Type: Primary
Antigen: CDKN2A
Clonality: Monoclonal
Clone: MX007
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG kappa
Reactivity: Human