- Antibody type:Primary
- Antigen name:p53
- Antigen symbol:TP53
- Clonality:Monoclonal
- Clone:Clone TRP/816
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG2a
- Reactivity:Human
- Western blot:Yes
- Gene ID:654481
- Antigen synonyms:Transformation Related Protein 53 (TRP53)|Tumor Protein p53|BCC7|Cellular Tumor Antigen p53|Tumor Suppressor p53|TP53|LFS1|Antigen NY-CO-13
- Storage buffer:PBS/0,05% azide
- Concentration:1 mg/mL
- Purification:BSA-free
- Size:50 μL
- Pk:50 µl
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Type: Primary
Antigen: TP53
Clonality: Monoclonal
Clone: TRP/816
Conjugation: Purified, BSA-free
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human