Ki-67 protein is a nuclear protein doublet plays a pivotal role in maintaining cell proliferation. In diagnostic histopathology and cell biology, the antibody has proven valuable for the demonstration of the Ki-67 antigen in normal and neoplastic cells, for example in soft-tissue sarcoma, prostatic adenocarcinoma, and breast carcinoma. It has been confirmed as a very powerful single prognostic factor for overall survival, with highly proliferative cases showing a much poorer outcome than tumors with low proliferation. In breast cancer, the proliferative index measured by Ki-67 immunoreactivity has both prognostic and predictive value.

• Control: Tonsil
• Dilution Range: 1:400-1:800 for immunohistochemical staining

Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer , pH 6,0 for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections.

Type: Primary
Antigen: MKI67
Clonality: Monoclonal
Clone: MIB-1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human