Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti- Factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases +), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma (-).^1-2 Anti-factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma.³

• Visualization: cytoplasmic
• Control: dermatofibroma
• Dilution Range: 1:100-1:500

References
1. Abenoza P, et al. Am J Dermatopathol. 1993; 15:429-34.
2. Horenstein MG, et al. Am J Surg Pathol. 2000; 24:996-1003.
3. Kraus MD, et al. Am J Dermatopathol. 2001; 23:104-11.

Type: Primary
Antigen: F13A1
Clonality: Monoclonal
Clone: EP3372
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human