- Antibody type:Primary
- Antigen name:Mutated in colorectal cancers
- Antigen symbol:MCC
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:C-Terminal
- Cross adsorption:No
- Form:Lyophilized
- Antigen synonyms:MCC-1|Mutated in colorectal cancers|CRCM_HUMAN.|MCC1|Colorectal mutant cancer protein|MCC 1|Protein MCC
- Amino acid number:573 to 590
- UniProtKB:P23508
- Sequence:IQQLKNDRAAVKLTMLEL
- Storage temperature:–20 °C
- Immunogen:A synthetic peptide corresponding to a sequence at the C-terminus of human MCC (573-590aa IQQLKNDRAAVKLTMLEL), identical to the related mouse and rat sequences.
- Purification:purified by immunogen affinity purification
- Size:100 µg
- Pk:100 µG
Rabbit IgG polyclonal antibody for Colorectal mutant cancer protein(MCC) detection. Tested with WB in Human;Mouse;Rat.
MUTATED IN COLORECTAL CANCERS(MCC) is a tumor suppressor gene. It is mapped to 5q22.2. This gene suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. MCC also Inhibits DNA binding of b-catenin/TCF/LEF transcription factors, and it is Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation. What's more, MCC can interact with SCRIB(via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2.
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Type: Primary
Antigen: MCC
Clonality:
Clone:
Conjugation:
Epitope: near the C-terminus
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat