Specifications
- Antibody type:Primary
- Antigen name:B and T lymphocyte associated
- Antigen symbol:BTLA
- Clonality:Monoclonal
- Clone:6F4
- Conjugation:Unconjugated
- ELISA:Yes
- Flow cytometry:Yes
- Host:Rat
- Isotype:IgG1
- Reactivity:Human
- Form:Liquid
- Gene ID:151888
- Antigen synonyms:Tumor Necrosis Factor Receptor Superfamily Member 3|Lymphotoxin-beta Receptor|B and T Lymphocyte Associated|Tumor Necrosis Factor Receptor 2 Related Protein|TNFRSF3|Tumor Necrosis Factor C Receptor
- Storage buffer:In PBS containing 10% glycerol.
- Storage temperature:Stable for at least 1 year after receipt when stored at -20˚C.
- Concentration:1 mg/ml
- Shipping temperature:-20°C
- Immunogen:Ectodomain of human BTLA fused to human IgG Fc.
- Tested applications:FACS, Func
- Purification:>95% (SDS-PAGE)
- Size:100 μg
- Pk:100 µG
Specifications
About this item
B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.
Type: Primary
Antigen: BTLA
Clonality: Monoclonal
Clone: 6F4
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG1
Reactivity: Human