Specifications
- Antibody type:Primary
- Antigen name:RENT1/hUPF1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Epitope:301-450/1129
- Form:Liquid
- Gene ID:5976
- Antigen synonyms:KIAA0221|Up framesht mutation 1 homolog|ATP-dependent helicase RENT1|Smg 2 homolog nonsense mediated mRNA decay factor|Regulator of nonsense transcripts 1|Nonsense mRNA reducing factor 1|NORF1|Smg 2|ATP dependent helicase RENT1|Delta helicase|pNORF1|pNORF 1|Up framesht mutation 1 homolog S. cerevisiae|RENT1_HUMAN|UPF1|HUPF1|UP Framesht 1|RENT 1|NORF 1|Up-framesht suppressor 1 homolog|RENT1|UPF 1 regulator of nonsense transcripts homolog|HUPF 1|UPF 1|Up framesht suppressor 1 homolog|Up-framesht mutation 1 homolog S. cerevisiae
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:124 kDa
- Storage temperature:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human RENT1/hUPF1
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (13). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.
Type: Primary
Antigen: RENT1/hUPF1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 301-450/1129
Host: Rabbit
Isotype: IgG
Reactivity: Others