Specifications
- Antibody type:Primary
- Antigen name:Peptidylprolyl Cis/trans Isomerase NIMA-interacting 1
- Antigen symbol:PIN1
- Clonality:Polyclonal
- Conjugation:Cy3®
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:5300
- Antigen synonyms:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|Rotamase Pin1|EC 5.2.1.8|UBL5|DOD|PPIase Pin1
- Modification:phospho-Ser16
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:1-50/163
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: PIN1
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat