Specifications
- Antibody type:Primary
- Antigen name:Toll-like Receptor 4
- Antigen symbol:TLR4
- Clonality:Polyclonal
- Conjugation:Cy3®
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Bovine,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:21898
- Antigen synonyms:TLR4|Toll-like receptor 4|Rasl2-8|TLR-4|Lps|Ran/M1|Ly87|hToll|CD284|ARMD10|TOLL
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:780-830/835
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
Recommended Dilutions: Flow Cytometry: 1:20-100; IF(IHC-P): 1:50-200; IF(ICC)(1:50-200
Type: Primary
Antigen: TLR4
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Bovine