Supplier: Bioss

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.

Supplier: Bioss

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.

Supplier: BIOTIX

This new generation of tips form an excellent seal on both single- and multi-channel pipettes guaranteeing total recovery of the sample whilst protecting the technician against the risks of repetitive strain injury. The tips are manufactured with proprietary technologies for increased pipetting accuracy and precision.

Supplier: Merck

LiChrospher® is Merck's reliable and versatile, traditionally-produced, spherical silica. LiChrospher® is available with different modifications.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, providing choice between applications and configurations that best suit the users' needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions. The Cubis® II range of high-capacity micro balances with a maximum load between 32 and 111 g and a readability between 0,001 mg and 0,002 mg provide the ideal choice for a broad range of applications.

Supplier: DELTALAB

RACK FOR CONTAINER 393X262X45MM (6X4) 1 * 1 items

Supplier: UVEX

LABCOAT MEN 473/WHITE MG SIZE XL 1 * 1 items

Supplier: Stirling Ultracold

The Stirling VAULT100 is the first ULT freezer with a −100 to −20 °C temperature range and the best steady-state setpoint adherence in the market.

Supplier: Dräger

TUBING RESPIRATORY TH2/TH3 X-PLORE 7000 1 * 1 items

Supplier: VITLAB

Volumetric cylinder, PMP, class A, KB, tall form, raised scale, 500 mL 1 * 2 items

Supplier: VITLAB

WIDE NECK BOTTLE, PP, 250 ML 1 * 12 items

Supplier: SAMCO

PASTEUR PIPETTE 5.8ML PE ST/10 1 * 4.000 items

Supplier: 3M

The 3M Speedglas Heavy-Duty Welding Helmet G5-01 builds on the 9100 series. Having more adjustable features than ever - from the colour as seen through the welding filter to the direction of the airflow and the level of coverage.

Supplier: MACHEREY-NAGEL

Printer paper rolls for URYXXON 500, URYXXON 300 and NANOCOLOR thermo printer Outer diameter:45mm Core diameter:12mm width:58mm pack of 5 rolls. 1 * 5 Roll

Supplier: KNICK

This portable Memosens-based instrument for the analysis of liquids can measure pH/ORP, conductivity (conductive/inductive), oxygen (amperometric/optical) and temperature and features direct printer control. A printer for immediate printing of the calibration record (GLP compliant) can be directly connected to the micro USB port. Waterproof according to IP 66/IP 67.

Supplier: Merck

ALUMINUM OXIDE 1 * 1 items

Supplier: witeg Labortechnik

Programmable Digital Muffle Furnace, Type FHP-14, with 4-side heating & program digital PID control system, temperature range: 300° - 1200°C, capacity: 14 Liter, internal: 250 x 350 x 160 mm, external: 530 x 580 x 620 mm, power: 4,0 kW,power supply: 1 * 1 items

Supplier: FRISTADS KANSAS

TRAVEL BAG 1699 BLACK 1 * 1 items

Supplier: CUSTOM MADE CHEMICALS LAB

7 COMPONENTS MIX 1 * 10 mL

Supplier: Merck

Fast method development of complex samples across the pH range from 1,5 to 10,5 with different mobile phases and temperature conditions.
Purospher® STAR RP-18 endcapped HPLC columns are designed for universal use. Basic, neutral and metal-chelating compounds can easily be separated with simple mobile phases – naturally without peak tailing. Thanks to its outstanding performance and stability, Purospher® STAR RP-18 endcapped offers maximum flexibility in method development. Robust methods can be developed over the entire pH range from 1,5 to 10,5. High pH-stability allows the separation of strongly basic compounds with alkaline eluents. The combination of high purity silica, best all-round retention characteristics, outstanding pH stability up to pH 10,5, and suitability for up to 100% aqueous mobile phases, make Purospher® STAR RP-18 endcapped an all-round top performance column, almost universal in its range of applications.

Supplier: CUSTOM MADE CHEMICALS LAB

56 COMPONENTS MIX 1 * 5 Ampoul

Supplier: Merck

PK20 CART. BTEX/VOCS, W/ACT CHARCOAL 1 * 20 items

Supplier: Cole-Parmer

320 - 380 BAND PASS FILTER 1 * 1 items

Supplier: Cole Parmer

Block Heater Insert, Single Wide, 30 x 0.5 mL Tubes 1 * 1 items

Supplier: Cole-Parmer

Dri-Block Aluminum Insert, 12 x 17 mm Dia Vial, Flat Bottom 1 * 1 items

Supplier: Sartorius

PE FABRIC 58MM 50PCS 1 * 50 items

Supplier: Cole Parmer

CHARGER 5V DC EURO 1 * 1 items

Supplier: Cole-Parmer

Dri-Block Aluminum Insert, 6 x 25 mm Dia, Conical Bottom 1 * 1 items

Supplier: HAMMACHER KARL

NEEDLE 50MM 1 * 1 items

Supplier: BIOCHROM

SPARE FILTER SET 1 * 1 items