R-(-)-Rolipram ≥98% (by HPLC)
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R-enantiomer of rolipram which is more active at inhibition of PDE IV, Ki=06 µM. 10-fold more active than S-rolipram at inhibition of PDE IV. Inhibits antigen-induced contraction of guinea-pig colonic smooth muscle, EC50=0.1 µM.
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N,N,2-Trimethyl-5-nitrobenzenesulphonamide (synthetic) ≥98% (by TLC)
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The first selective PDE7 inhibitor (Ki=180 nM).
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Sivelestat sodium ≥98% (by HPLC)
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Potent and selective leukocyte elastase inhibitor (IC50=44nM). Displays various anti-inflammatory activities including attenuation of LTB4-induced neutrophil migration and serum cytokine levels. Reduces acute inflammatory lung injury in vivo.
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BMOV ≥96% (by TLC)
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Organic vanadium complex which acts as a potent insulin mimic.
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PF-356231 ≥98% (by TLC)
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Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.
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Gabexate mesylate ≥98% (by HPLC)
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A competitive, reversible inhibitor of serine proteases tryptase (Ki=3.4nM), thrombin (Ki=500nM), uPA (Ki=1.3µM), plasmin (Ki=1.5µM), trypsin (Ki=2µM), factor Xa (Ki=2µM). At higher concentrations it inhibits kallikrein-1 (Ki=2.6mM), C1 esterase (IC50=520µM), as well as phospholipase A2 (IC50=500µM), rat iNOS (Ki=5mM) and cNOS (Ki=150µM), and swine kidney copper amine oxidase (Ki=27µM), but not chymotrypsin. Has been used in tissue culture and in vivo. In clinical use for pancreatitis.
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Argatroban ≥98% (by HPLC)
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Argatroban is a synthetic peptidomimetic thrombin inhibitor which is in clinical use. It presents significant advantages as an anticoagulant in deep vein thrombosis, stroke prevention in atrial fibrillation and thromboembolic disease and especially in patients with coronary artery disease and heparin-induced thrombocytopenia.
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Pseudohypericin ≥98% (by HPLC, TLC)
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Inhibitor of PKC and dopamine beta-hydroxylase
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Xanthorrhizol ≥97% (by HPLC)
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Antibacterial and anti-inflammatory compound. Apoptosis inducer.
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(-)-Arctigenin (from Arctium lappa) ≥97% (by HPLC)
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Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells. Antagonist for platelet activating factor and Ca²⁺. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.
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Auraptene ≥95% (by UPLC)
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Anti-inflammatory and chemopreventive.
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Leptomycin B 0.2 mg/ml ≥98% (by HPLC)
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A potent and specific nuclear export inhibitor. In addition to antifungal and antibacterial activities, blocks the cell cycle and is a potent anti-tumor agent.
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3,5,7,4'-Tetrahydroxy-3',5'-dimethoxyflavylium chloride ≥97% (by HPLC)
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Cell cycle inhibitor
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3,3',4',5,7-Pentahydroxyflavylium chloride ≥97% (by HPLC)
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Nitric oxide (NO) scavenger.
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S-Nitrosoglutathione (GSNO) ≥98% (by TLC)
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Nitric oxide donor
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8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer triethylammonium salt ≥99% (by HPLC), high purity
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Potent selective inhibitor of cGMP-dependent protein kinase 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS or Rp-8-Br-cGMPS.
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Vitamin A acetate (synthetic) ≥95% (by HPLC)
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Vitamin A acetate (synthetic) ≥95% (by HPLC)
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