Supplier: Bioss

DNA double-strand breaks can be generated by exposure to ionizing radiation or through endogenous cellular reactions. Double-strand breaks are generally thought to be repaired via one of two distinct mechanisms: homologous recombination (HR) or non-homologous end joining (NHEJ). Homologous recombination requires the activity of the members of the RAD52 epistasis group, which include RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2. RAD52 can catalyze strand annealing reactions, and can form oligomers that attach to ends of single-stranded DNA.

Supplier: Bioss

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP alpha, CEBP delta, and CEBP gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL1 response element in the IL6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.

Supplier: Bohlender

Canister with S60/61 thread (DIN 60/61) for the collection of liquid waste with integrated indicator to monitor the level.

Supplier: Biotium

Near-IR Annexin V fluorescent conjugates can be used to detect apoptotic cells and is suitable for in vivo imaging.

Supplier: Bioss

Twisted Gastrulation Protein 1(TWSG1) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins thereby preventing BMPs from binding to their receptors. It can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex.

Supplier: Bioss

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Supplier: Bioss

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Supplier: ENZO LIFE SCIENCES

Aqua 431 [DEAC] dUTP is a coumarin derivative that can replace TTP in reactions in which it serves as a substrate for E. coli DNA polymerase (holoenzyme and Klenow fragment), T4 and Taq DNA polymerases, reverse transcriptase (from AMV and M-MuLV) and terminal transferase. Fluorescently labelled probes can be prepared with this fluorescent nucleotide by a variety of methods including nick translation, random prime labelling, cDNA labelling and 3’-end labelling. Probes generated by these methods are suitable for use for the identification of specific sequences by in situ hybridization procedures on fixed cells and tissues by direct fluorescence detection. Aqua 431 dUTP can also be used for multicolor fluorescence labelling.

Supplier: ENZO LIFE SCIENCES

Red 580 [5-ROX] dUTP can replace TTP in reactions in which it serves as a substrate for E. coli DNA polymerase (holoenzyme and Klenow fragment), T4 and Taq DNA polymerases, reverse transcriptase (from AMV and M-MuLV) and terminal transferase. Fluorescently labelled probes can be prepared with this fluorescent nucleotide by a variety of methods including nick translation, random prime labelling, cDNA labelling and 3’-end labelling. Probes generated by these methods are suitable for use for the identification of specific sequences by in situ hybridization procedures on fixed cells and tissues by direct fluorescence detection. Red 580 dUTP can also be used for multicolor fluorescence labelling.

Supplier: VWR Chemicals

Gold-N-Gel RNA dye is compatible with standard protocols for denaturing electrophoresis of RNA fragments. Bands are immediately visible upon illumination with UV light. A standard ethidium bromide filter can be used for gel documentation.

Supplier: Biotium

The fluorescence of NBD is highly dependent on the environment; it is virtually nonfluorescent in water but becomes strongly green fluorescent in hydrophobic media. NBD-ethylenediamine can be readily coupled to activated carboxy groups or sulfonyl chlorides.

Supplier: VWR Collection

Rack, Test tube, VWR®, Stainless steel test tube rack, holds maximum of 15 tubes. 6 litre stainless steel baths can accommodate 1 rack, Stainless steel, For tube Ø: 14 - 18 mm

Supplier: Bohlender

b.safe waste tubes can be connected to the canister by means of these b.safe system waste caps and solvents can be collected safely. Solvent vapours are held back by the exhaust filter with activated carbon or can be led to the hood by means of a venting hose.

Supplier: Bioss

FOXB1 and FOXB2 are winged helix/forkhead transcription factors. FOXB1 is specifically expressed in the developing central nervous system (CNS). Early embryonic FOXB1 expression is restricted to the mammiliary body region of the caudal hypothalamus, midbrain, hindbrain and spinal cord. FOXB1 may play a role in postnatal growth, lactation and CNS development.

Supplier: Bioss

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Supplier: Bioss

FOXB1 and FOXB2 are winged helix/forkhead transcription factors. FOXB1 is specifically expressed in the developing central nervous system (CNS). Early embryonic FOXB1 expression is restricted to the mammiliary body region of the caudal hypothalamus, midbrain, hindbrain and spinal cord. FOXB1 may play a role in postnatal growth, lactation and CNS development.

Supplier: VWR Chemicals

The VWR® Matrix modifier solutions have especially been developed for use in GF-AAS to eliminate matrix effects. They can be used either diluted or as mixtures.

Supplier: Bioss

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Supplier: VWR Collection

Silane coated (aminoalkylsilane) glass slides producing a sticky surface, which can bind tissue sections to glass.

Supplier: TENAK

Complete range of racks for microtiter plates for use in upright freezers, made of stainless steel. The racks can either be used as one plate per shelf or the plates can be stacked.

Supplier: Shenandoah Biotechnology

Cytokines for polarizing human T cells into Th9 cells. Th9 cells are a unique subset of T helper cells that produce IL-9. An important function of IL-9 producing T cells is fighting inflammation and helminth infections. Th9 cells can be generated from naive CD4+ T cells in culture by culturing them in the presence of IL-4 and TGF-β 1. It also appears that IFNγ and IL-27 can inhibit the generation of Th9 cells.

Supplier: Columbia Biosciences

SureLight™ P3 is a proprietary dye can be used in prompt fluorescent detection, microplate applications, flow cytometry and protein microarrays.

Supplier: Biotium

Membrane-impermeant calcium indicator that can be loaded into cells via microinjection or scrape loading.

Supplier: ENZO LIFE SCIENCES

Antipsychotic working on a variety of receptors in the CNS

Supplier: Apollo Scientific

Can be used to introduce the pentafluorophenyl group viapentafluorophenyllithium. For a review of the effects of thepentafluorophenyl group: Fluorine Chem. Rev.,8, 1 (1997)

Supplier: UVEX

These polycarbonate and cellulose acetate visors can be attached to helmets by using a length adapter and can be locked in three positions.

Supplier: Trajan Scientific and Medical

A high-capacity gas purifying system that can remove a combination of oxygen, moisture and hydrocarbons, (greater than C4) from inert gases and hydrogen.

Supplier: VWR Collection

3D cubic bags can fit in existing support containers. These support containers are available in either High Density Polyethylene (HDPE) and Polypropelene (PP), or stainless steel material.

Supplier: Saint Gobain Life Sciences

Pure-Fit SIB eliminates entrapment and leak points that can occur with traditional assembly systems. The unique internal design eliminates voids or dead space that can lead to turbulence or stagnation of fluid flow creating the potential for bacterial growth.

Supplier: Bioss

The WRCH1 protein is a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation.