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42864 results for "ProSci Inc."

42864 Results for: "ProSci Inc."

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Human recombinant Fam171 B1 (from HEK293 cells)

Human recombinant Fam171 B1 (from HEK293 cells)

Supplier: ProSci Inc.

Family with sequence similarity 171, member B (FAM171B) is also known as KIAA1946, NPD019, which is a single-pass type I membrane protein, belongs to the FAM171 family.

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Anti-MSMO1 Rabbit Polyclonal Antibody

Anti-MSMO1 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases.Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Anti-AP2B1 Rabbit Polyclonal Antibody

Anti-AP2B1 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

AP2B1is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. AP2B1 is found on the cytoplasmic face of coated vesicles in the plasma membrane.The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.

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Anti-P2RX4 Goat Polyclonal Antibody

Anti-P2RX4 Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-P2RX4 Goat Polyclonal Antibody

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Anti-ABCC8 Goat Polyclonal Antibody

Anti-ABCC8 Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-ABCC8 Goat Polyclonal Antibody

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Anti-CHRNA4 Goat Polyclonal Antibody

Anti-CHRNA4 Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-CHRNA4 Goat Polyclonal Antibody

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Anti-AK4 Rabbit Polyclonal Antibody

Anti-AK4 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

AK3L1 is a member of the adenylate kinase family of enzymes. The protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides.This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1.

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Anti-RNF25 Rabbit Polyclonal Antibody

Anti-RNF25 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Anti-RNF25 Rabbit Polyclonal Antibody

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Anti-MMP3 Rabbit Polyclonal Antibody

Anti-MMP3 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Anti-MMP3 Rabbit Polyclonal Antibody

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Anti-CALB2 Rabbit Polyclonal Antibody

Anti-CALB2 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Anti-CALB2 Rabbit Polyclonal Antibody

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Anti-SRPX2 Rabbit Polyclonal Antibody

Anti-SRPX2 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Anti-SRPX2 Rabbit Polyclonal Antibody

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Anti-EPAS1 Rabbit Polyclonal Antibody

Anti-EPAS1 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Anti-EPAS1 Rabbit Polyclonal Antibody

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Anti-ZNF683 Rabbit Polyclonal Antibody

Anti-ZNF683 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

This gene, ZNF683, which is located on chromosome 1, is predicted to encode a zinc finger protein, currently with unknown fucntion.

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Anti-ZFP42 Rabbit Polyclonal Antibody

Anti-ZFP42 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

ZFP42 is a transcription factors and a specific marker of undifferentiated embryonic stem (ES) cells.

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Anti-EBI3 Rabbit Polyclonal Antibody

Anti-EBI3 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

EBI3 Antibody: EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35. Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.

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Anti-IL16 Rabbit Polyclonal Antibody

Anti-IL16 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

IL-16 Antibody: IL-16 was initially identified as a chemotactic cytokine, but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases. The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20 kDa active form that binds to and signals through CD4. Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders. At least two isoforms of IL-16 are known to exist; the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus.

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Anti-EBI3 Rabbit Polyclonal Antibody

Anti-EBI3 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

EBI3 Antibody: EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35. Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.

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Anti-PRICKLE2 Rabbit Polyclonal Antibody

Anti-PRICKLE2 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

PRICKLE2 Antibody: PRICKLE2, also known as Pk2 or EPM5, is a member of a highly conserved protein family that function in the noncanonical WNT signaling pathway which regulates intracellular calcium release and planar cell polarity. Both PRICKLE2 and the related protein PRICKLE1 are expressed in postmitotic neurons and promote neurite outgrowth, and both proteins promote neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. PRICKLE2 localizes to the postsynaptic density and interacts with PSD-95 and NMDA receptors. Defects in the gene encoding PRICKLE2 are associated with autosomal recessive progressive myoclonic epilepsy.

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Anti-SDF2 Rabbit Polyclonal Antibody

Anti-SDF2 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

SDF2 is believed to be a secretory protein. It has regions of similarity to hydrophilic segments of yeast mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals. The protein encoded by this gene is believed to be a secretory protein. It has regions of similarity to hydrophilic segments of yeast mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals.

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Anti-CASP12 Rabbit Polyclonal Antibody

Anti-CASP12 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

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Anti-SARS SPIKE Rabbit Polyclonal Antibody

Anti-SARS SPIKE Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

SARS Spike Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

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Anti-APP Rabbit Polyclonal Antibody

Anti-APP Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

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Human SCO2 peptide

Supplier: ProSci Inc.

SCO2 peptide is used for blocking the activity of SCO2 antibody.

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Mouse recombinant IL-6 non-lytic (from CHO cells)

Supplier: ProSci Inc.

Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kDa-28kDa phosphorylated and variably glycosylated molecule. IL-6 induces signallling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.

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Anti-EPB41L5 Goat Polyclonal Antibody

Anti-EPB41L5 Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-EPB41L5 Goat Polyclonal Antibody

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Anti-IL6 Rabbit Polyclonal Antibody

Anti-IL6 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. In addition, IL-6 appears to interact with IL2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.

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Anti-IL5 Rabbit Polyclonal Antibody

Anti-IL5 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Interleukin 5 (IL-5) is a cytokine produced primarily by activated T lymphocytes. It exists as an antiparallel disulfide linked homodimeric glycoprotein with 115 amino acid residues in each chain. Known also as EDF (eosinophil differentiating factor), functions predominantly as an eosinophilopoietic factor. Analysis of its crystal structure reveals a novel two domain structure, with each domain showing significant homology to the cytokine fold in GMCSF, MCSF, IL-2, IL-4 and growth hormone. Human and mouse IL-5 have 70% amino acid sequence homology.

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Anti-GABRG3 Rabbit Polyclonal Antibody

Anti-GABRG3 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.

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Anti-GLI1 Rabbit Polyclonal Antibody

Anti-GLI1 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

GLI1 is a protein which is a member of the Kruppel family of zinc finger proteins. The function of this gene has not been determined; however, it may play a role in normal development gene transcription. Mouse mutation studies indicate possible involvement in human foregut malformation.

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Anti-LZTFL1 Rabbit Polyclonal Antibody

Anti-LZTFL1 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

The function remains unknown.

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