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43961 results for "N\\\\\\\'-Hydroxy-4-imidazo[1,2-a]pyridin-2-ylbenzenecarboximidam"

43961 Results for: "N\\\\\\\'-Hydroxy-4-imidazo[1,2-a]pyridin-2-ylbenzenecarboximidam"

Anti-ATG12 Rabbit Polyclonal Antibody

Anti-ATG12 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

ATG12 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.

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Removable needles

Removable needles

Supplier: HAMILTON BONADUZ

The benefit of a replaceable needle for the occasional bend or clog and the minimal dead volume of a cemented needle. The unique removable needle design installs the needle precisely at the zero line. The result is a zero dead volume connection that simplifies priming.

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Anti-KLF12 Rabbit Polyclonal Antibody

Anti-KLF12 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. KLF12 is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1.Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.

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VWR® CompactStar CS8, Centrifuge

VWR® CompactStar CS8, Centrifuge

Supplier: VWR Collection

The CompactStar CS8 is a small ventilated bench top centrifuge designed for the separation of various samples in the fields of chemistry, life science, clinical research and routine diagnostics. The supplied rotor accepts 8×15 ml conical tubes, 8×15 ml (16×125 mm) round bottom and 8×10 ml (16×100 mm) blood collection tubes directly and smaller tubes with an included adapter set.

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VWR® Premium 150, Premium 90 HR, Automatic Colony Counters

VWR® Premium 150, Premium 90 HR, Automatic Colony Counters

Supplier: VWR Collection

Premium 150 and Premium 90 HR colony counters and zone measurements systems.

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Quantus® Comfort, Cleanroom Overalls

Quantus® Comfort, Cleanroom Overalls

Supplier: VWR Collection

These overalls are made from Quantus® Comfort fabric which is a high quality polyester fabric (100 % polyester weave with conductive yarn) designed for critical cleanroom applications. The fabric provides a very high wearing comfort and at the same time a great barrier against particles (98% for airborne particles >0,3 μm).

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VWR® SMART5 XE Gel Documentation System

VWR® SMART5 XE Gel Documentation System

Supplier: VWR Collection

SMART5 XE is a new generation of an integrated gel imaging and gel documentation system dedicated for the detection and analysis of DNA and protein.

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Anti-CXCL12 Rabbit Polyclonal Antibody (Cy5®)

Supplier: Bioss

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

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Perfection and Performance Laboratory Underbench Freezers, SFTvh and SFTsg

Perfection and Performance Laboratory Underbench Freezers, SFTvh and SFTsg

Supplier: Liebherr

Underbench freezers with forced air or static cooling. White steel exterior and commercial-grade polystyrol interior. The intuitive user interfaces provide useful extended multi-functionality, e.g. a maintenance timer. Advanced connectivity options to suit varying requirements for simplified data storage, temperature control and alarm signals.

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NHS-Activated magnetic beads, Pierce™

NHS-Activated magnetic beads, Pierce™

Supplier: Thermo Fisher Scientific

The Pierce™ NHS-activated magnetic beads enable covalent, amine-based conjugation of proteins to magnetic beads in a simple mix-and-go format for use in custom affinity purification experiments.

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HPLC columns, SeQuant® ZIC®-HILIC

HPLC columns, SeQuant® ZIC®-HILIC

Supplier: Merck

The selectivity offered by ZIC®-HILIC is suitable for a wide variety of molecules containing hydrophilic or ionisable functional groups. This includes compounds such as carbohydrates, metabolites, acids and bases, organic and inorganic ions, metal complexes, amino acids, peptides, protein digests, plant and cell extracts, plus much more. Such compounds are normally characterised by a small or negative LogP value and have poor retention on reversed-phase columns.

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Blood collection tubes, with EDTA, VACUETTE®

Blood collection tubes, with EDTA, VACUETTE®

Supplier: Greiner Bio-One

EDTA tubes are ideal for the examination of whole blood in haematology and are offered as either K2EDTA or K3EDTA tubes.

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High visibility overalls, lined, S485

High visibility overalls, lined, S485

Supplier: Portwest

These overalls are made from 300D Oxford Weave fabric (300 denier polyester yarn) which features a high abrasion and tear resistance. The PU coating on the inside makes the fabric durable and waterproof, while the outer has a water- and stain-repellant coating which helps keep the garment clean. Ideal for use in dark, cold and wet conditions.

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Canine Lactoferrin ELISA Kits

Supplier: Antibodies.com

Canine Lactoferrin ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of canine Lactoferrin in serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

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Human Adipolin ELISA Kit

Supplier: Antibodies.com

Human Adipolin ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Adipolin in tissue homogenates, cell lysates or other biological fluids.

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Rat mTOR ELISA Kits

Supplier: Antibodies.com

Rat mTOR ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat mTOR in tissue homogenates, cell lysates or other biological fluids.

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Digital multi-tube vortex, MULTI-TX5

Digital multi-tube vortex, MULTI-TX5

Supplier: VELP SCIENTIFIC

The MULTI-TX5 Digital is the ideal digital multi-tube vortex mixer for high sample throughput. The innovative and compact design ensures maximum operating comfort for mixing applications requiring different test tubes.

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Funnel with ball and lid, electrostatic conductive, ARNOLD, V2.0

Funnel with ball and lid, electrostatic conductive, ARNOLD, V2.0

Supplier: S.C.A.T.

The strong and electrically conductive safety funnel 'ARNOLD' V2.0 with lid and ball meets the highest requirements for safe disposal of hazardous liquid waste due to its combination of two independent safety mechanisms. The two safety features consist of a ball integrated in the funnel basin and a sealing ring incorporated in the hinged lid of the funnel, which prevent the escape of toxic gases. The funnel is especially designed for explosive or flammable substances, as the PE-HD material used is eclectically conductive and charges can be dissipated via the ground cable.

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Production and laboratory chairs, with permanent contact backrest, Neon 3

Production and laboratory chairs, with permanent contact backrest, Neon 3

Supplier: bimos

Neon supports the forward-leaning sitting position that is often necessary in lab work. Its modern design matches the high-tech laboratory environment perfectly and of course it has all the characteristics you would expect of a good laboratory chair. It is seamless, easy to clean, washable, and resistant to disinfectants. So, Neon is the ideal solution for the laboratory, when a really comfortable ergonomic chair is needed.

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Syringe filters certified for HPLC sample prep, SPARTAN™, Whatman™

Syringe filters certified for HPLC sample prep, SPARTAN™, Whatman™

Supplier: Whatman products (Cytiva)

SPARTAN syringe filters with regenerated cellulose (RC) membrane provide reproducible filtration of organic and aqueous solutions for high performance and ultra-high performance liquid chromatography (HPLC and UHPLC) sample preparation.

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Flame-retardant rain trousers, high visibility, Gladstone 5729

Flame-retardant rain trousers, high visibility, Gladstone 5729

Supplier: SIOEN

These lightweight, breathable trousers made of Siopor® FR AST fabric (100% polyester fabric with 100% FR PU coating + AST) are waterproof and windproof and have anti-static features. The fixed cotton lining is flame-retardant. The trousers provide good tear resistance and protection against rough weather conditions.

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Permanent Cryogenic Labels for Laser Printers

Permanent Cryogenic Labels for Laser Printers

Supplier: GA

Permanent cryogenic laser labels for long-term storage in liquid phase and vapor phase liquid nitrogen (−196 °C), lab freezers (−80 °C), and on dry ice. Supplied in A4 sheet format for printing in standard desktop laser printers, these cryogenic labels do not jam printers and withstand UV and gamma irradiation.

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Isolator Cleaning Tools

Isolator Cleaning Tools

Supplier: MICRONOVA

The Isolator Tool™ adapter with a 360° swivel works with a range of mop covers to efficiently clean and disinfect isolators, hoods, RABS, and small equipment in clean and aseptic areas.

   Sustainable Options Available
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Flathead mop covers, SnapMop™

Flathead mop covers, SnapMop™

Supplier: MICRONOVA

A range of lightweight, snap-on flat head mop covers with urethane foam interiors, designed for effective cleaning and sanitising in the cleanroom. A variety of fabric options provide excellent absorbency, effective cleaning, and disinfectant dispersal for specialised cleaning.

   Sustainable Options Available
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Human mTOR ELISA Kit

Supplier: Antibodies.com

Human mTOR ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human mTOR in tissue homogenates, cell lysates or other biological fluids.

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Human KCC2 ELISA Kit

Supplier: Antibodies.com

Human KCC2 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human KCC2 in serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

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Flame-retardant rain jacket, high visibility, Hedland 7223

Flame-retardant rain jacket, high visibility, Hedland 7223

Supplier: SIOEN

This waterproof and windproof jacket is made of anti-static Siopor® FR AST fabric: 100% polyester fabric with 100% FR PU coating + AST. Inside it features a fixed flame-retardant cotton lining with two pockets. The outer fabric is water-repellent, while the coating on the inside attracts moisture and keeps the skin dry.

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Flame-retardant rain jacket, high visibility, Falcon 7229

Flame-retardant rain jacket, high visibility, Falcon 7229

Supplier: SIOEN

This waterproof and windproof jacket is made of Siopor Excell, a 3-layer fabric consisting of Dobby Ripstop polyester fabric + AST - breathable FR PU coating and an inherent FR knitting. The outer fabric is water-repellent, while the coating on the inside attracts moisture and keeps the skin dry.

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Anti-CXCL12 Rabbit Polyclonal Antibody (Cy3®)

Supplier: Bioss

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

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High visibility rain jackets, PW3, T400 Vision Hi-Vis

High visibility rain jackets, PW3, T400 Vision Hi-Vis

Supplier: Portwest

The stylish and functional rain jacket will ensure you stand out from the crowd. Made from 300D Oxford PU coated durable stain resistant fabric, this jacket features the new Insulatex heat reflective lining panel, which reflects heat back into the body ensuring maximum warmth and comfort.

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