124562 Results for: "N\\\\\\\\u00E1stroje+na+m\\\\\\\\u00EDch\\\\\\\\u00E1n\\\\\\\\u00&pageNo=12"

Supplier: Abcam

Mouse monoclonal [H90-10] to Hsp90 beta.

Supplier: Abcam

Rabbit monoclonal [EPR19660-167] to IL-11 - BSA and Azide free (Capture).

Supplier: Abcam

Mouse monoclonal [KRT10/844] to Cytokeratin 10 - BSA and Azide free.

Supplier: Bioss

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.

Supplier: Apollo Scientific

1-(2,5-Difluorophenyl)-N-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]methanamine

Supplier: Tonbo Biosciences

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

Supplier: Abcam

Mouse monoclonal [DC 10] to Cytokeratin 18.

Supplier: Abcam

Rabbit monoclonal [EPR28415-13] to NOX2/gp91phox - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR25897-10] to SMN/Gemin 1 - BSA and Azide free (Capture).

Supplier: Thermo Fisher Scientific

Gold ≥99.9% (metals basis), ultrathin foil, Thickness: 1.0 µm

Supplier: Biotium

Recognizes a glycoprotein of ~200 kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.

Supplier: Apollo Scientific

Methyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate 99%

Supplier: Apollo Scientific

3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid 97%

Supplier: Thermo Fisher Scientific

Vanadium ≥99.5% (metals basis), foil, Thickness: 1.0 mm (0.04 in)

Supplier: Thermo Fisher Scientific

Lead ≥99.9998% (metals basis), rods, Puratronic®, Ø 12.7 mm (0.5 in)

Supplier: Tonbo Biosciences

The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

Supplier: Apollo Scientific

[1-(4,6-Dimethyl-2-pyrimidinyl)-5-(hydroxymethyl)-1H-1,2,3-triazol-4-yl]methanol

Supplier: Bioss

Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH10 (protocadherin 10), also known as PCDH19 or OL-PCDH, is a 1,040 amino acid single-pass type I membrane protein that contains six cadherin domains and one transmembrane domain. Expressed at moderate levels in brain, ovary and testis and present at lower levels in all other tissues, PCDH10 functions as a calcium-dependent cell-adhesion protein that may function as a tumor suppressor. When underexpressed, PCDH10 is associated with the progression of various carcinomas, including gastric cancer.

Supplier: Abcam

Rabbit monoclonal [EPR15425(B)] to Aldehyde dehydrogenase 10 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR9655(B)] to 14-3-3 gamma/YWHAG - BSA and Azide free.

Supplier: US Biological

Anti-Brain Natriuretic Peptide Mouse Monoclonal Antibody [clone: 1-11-7]

Supplier: Bioss

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Supplier: Thermo Fisher Scientific

(+/-)-3,4,8,8a-Tetrahydro-8a-methyl-1,6(2H,7H)-naphthalenedione ≥98%

Supplier: US Biological

Anti-TNFRSF13B Rat Monoclonal Antibody (Biotin) [clone: 1A-10]

Supplier: Abcam

Mouse monoclonal [rCDH16/1071] to Cadherin 16 - BSA and Azide free.

Supplier: Thermo Fisher Scientific

Copper ≥99.9999% (metals basis), wire, Puratronic®, Ø 1.5 mm (0.06 in)

Supplier: Apollo Scientific

4,4,5,5-Tetramethyl-2-(3,3,5,5-tetramethylcyclohex-1-en-1-yl)-1,3,2-dioxaborolane 97%

Supplier: Apollo Scientific

(2,3-Dihydro-3-oxo-4H-1,4-benzothiazin-4-yl)acetic acid

Supplier: Biotium

Recognizes a protein of 74 kDa, identified as CD84 (Workshop V; Code A085, C057). It is expressed on mature B cells and on B-cell lines, including pre-B-cell lines, but not on plasma cell lines. Immunohistochemical studies demonstrated that CD84 strongly expressed on tissues macrophages. CD84 is also highly expressed on platelets and, at low levels on peripheral blood T cells. It is a highly N-glycosylated protein and belongs to immunoglobulin superfamily. It may play a role in leukocyte activation.

Supplier: Bioss

The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-10 is a 228 amino acid multi-pass membrane protein that belongs to the claudin family and plays an important role in cell-adhesion activity and tight junction-specific events.