6489 Results for: "Hydroxid-uhli\\u010Ditan+ho\\u0159e\\u010Dnatý&pageNo=28&view=list"

Supplier: Bioss

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

Supplier: Bioss

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

Supplier: Avantor Fluid Handling

Versatile pumps for process applications – with an intuitive touch-screen interface and advanced connectivity.

Supplier: Avantor Fluid Handling

Complete pump systems for accurate fluid delivery - with an intuitive touch-screen interface.

Supplier: IKA

The INC 125 FS digital incubator shakers have a removable shaker platform. Without the platform, the units can be used as a normal incubator. The large inner chamber with a volume of 125 L offers space for up to 6 grid shelves (without shaker platform). Thanks to high temperature stability and a uniform shaking motion that improves oxygenation, the incubator shakers are the perfect solution for cell cultivation and other microbiological applications.

Supplier: Thermo Scientific

Thermo Scientific™ TDE Series ‒40 °C ultra-low temperature freezers, powered by H-drive, feature three upright models, maximizing storage capacity from 40000 up to 60000 2 ml vials. The TDE Series is a sustainable and reliable solution with ultimate sample security and operational savings for every laboratory.

Supplier: Avantor Fluid Handling

Versatile gear pump drives for high-accuracy, pulseless fluid delivery – with an intuitive touch-screen interface.

Supplier: Bioss

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

Supplier: Bioss

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

Supplier: Bioss

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

Supplier: Bioss

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

Supplier: Thermo Fisher Scientific

The Thermo Scientific™ IntelliStack™ CO₂ Incubator shaker is a versatile laboratory instrument used for incubating and agitating samples simultaneously. It combines the functions of an incubator and shaker, providing a controlled environment for cell culture, microbial growth, and various other applications. With adjustable temperature, speed, and CO₂ concentration settings, it offers precise control over experimental conditions. A large, easy-to-use 10" colour touchscreen display with alarms, alerts, real-time monitoring of key parameters, and data logging with export via USB or Ethernet allows for easy operation.

Supplier: Mettler - Toledo

These portable meters provide high quality pH/mV measurements with the simple click of a button. The robust and waterproof design makes the FiveGo instruments the perfect companion to get reliable measurement data even in harsh conditions. Ideal for mobile applications in the laboratory, at-line, or outdoors.

Supplier: OHAUS

A range of balances that incorporate a touch screen, advanced weighing and proximity sensor technologies. The easy to use control unit can be mounted on a base, above a base on an optional column, on a wall, or remotely (up to 3 metres distant with an optional cable). The touch screen display, with universal icons and informative prompts, simplifies set-up functions and basic operation. Then the operator has the added choice to use proximity sensors for hands-free operation when handling sensitive samples. These balances have multiple application modes from basic weighing to SQC applications, together with short stabilisation times and optimised performance specifications.

Supplier: OHAUS

The Pioneer PX series of semi-micro balances combines essential weighing functionality with performance, offering high accuracy and repeatability for basic applications in laboratory, industrial and education settings. PX models are economically priced, and intuitively designed for intelligent operation. Their durable design has a cast metal lower housing, metal sub-pan and stainless steel weighing pan for long-term use.

Supplier: Avantor

Suitable for use on Tecan Freedom EVO or Tecan Fluent. Available in conductive and non conductive versions, with or without filter, and in CE-IVD marked version for clinical diagnostic applications.

Supplier: Sartorius Balances

Cubis® II MCE precision balances with essential user interface offer a maximum load between 320 and 14200 g and a readability of 1 to 100 mg provide, ideal model for every application.

Supplier: VWR Collection

VWR® Imager gel documentation and analysis systems are available in configurations suitable for fluorescence and chemiluminescence applications. Both models are fitted with a digital CCD camera (3,8 or 4 MP) which utilises the latest USB technology. The standard system features a 12-bit CCD camera that can be software modified to 16-bit. The CHEMI Premium system is equipped with a true 16-bit advanced cooled CCD camera able to capture images of a wide range of chemiluminescent samples using common substrates.

Supplier: Thermo Fisher Scientific

The Thermo Scientific™ IntelliStack™ Incubator shaker is a versatile laboratory instrument used for incubating and agitating samples simultaneously. It combines the functions of an incubator and shaker, providing a controlled environment for cell culture, microbial growth, and various other applications. With adjustable temperature, speed, and humidity settings, it offers precise control over experimental conditions. A large, easy-to-use 10" colour touchscreen display with real-time monitoring of key parameters and alarms, alerts, and data logging with export via USB or Ethernet allows easy operation, enabling users to set and maintain specific temperature, speed, humidity level, and duration parameters to meet the requirements of various applications.

Supplier: SI Analytics

The number of samples to be processed is growing constantly while at the same time the demands on reliability are increasing in accordance with GLP and ISO standards. The SI Analytics sample changer (TW 7200) helps you meet these increased requirements and free up highly qualified employees from routine work. TW 7200 basic unit with two integrated magnetic stirrers, including external power supply 100 to 240 V with adapters for EU, US and UK, USB cable for direct PC connection and connection cable for rod stirrer.

Supplier: Binder

These ultra-low temperature freezers ensure the safe storage of samples at –90 °C. They combine outstanding environmental friendliness with low energy consumption, convenient operation and an individual safety concept.

Supplier: EPPENDORF

The robust Reference® 2 is the successor to the Reference® pipette and features a new design, reduced weight and unique one-button operation.

Supplier: Corning

These thermoconductive modules provide reproducible and standardised temperature control to biological samples while on the bench.

Supplier: VWR Collection

Designed to hold multiple test tubes, test tube racks, vials or cylinders. Vortexing action is created by securing the top of the vessel in place while allowing the bottom to move freely in a defined orbit. Two stainless steel posts hold the support plate securely in place for quiet, rattle-free mixing. The support plate is easily adjustable by loosening knobs and moving the support plate up and down. The circular groove around the top of the taller post allows the support plate to be swung away from the tray for easy removal of samples. The suction cup feet dampen motion and prevent the unit from moving along the work bench. Made from stainless steel with corrosion resistant paint. Equipped with a powerful, permanent magnet motor with sealed ball bearings. Motor is rated for continuous duty.

Supplier: ROBU GLASFILTER

ROBU® filter crucibles with heating mantle and standard joints offers controlled filtration and temperature regulation, ideal for vacuum filtration and thermally sensitive applications, optionally available with integrated VitraPOR® filter.

Supplier: Thermo Fisher Scientific

Finnpipette™ F2 offers superior robustness and durability even in the most demanding applications.

Supplier: Thermo Fisher Scientific

These Nunc™ cell culture flasks are designed for culture consistency, cell health, and reproducibility. Choose from a variety of surfaces and sizes with culture areas ranging from 25 to 500 cm² to suit your specific applications and cell types.

Supplier: Mettler - Toledo

These bench top instruments provide high quality pH/mV measurements with the simple click of a button. Thanks to their intuitive operation, sleek design and simple data export functions they are easy to set up and to use. Ideal for use in food and beverage processing, agriculture, environment, industry and for education purposes.

Supplier: Avantor Fluid Handling

Versatile piston pump drives for high-accuracy fluid dispensing and delivery – with an intuitive touch-screen interface.

Supplier: Avantor Fluid Handling

High-flow pump for process applications – with an intuitive touch-screen interface and advanced connectivity.